Gastrin is a peptide hormone produced by mucosal G cells of the gastric antrum. It is synthesized as preprogastrin, cleaved to progastrin, which undergoes several posttranslational modifications, in particular sulfation, and is finally processed into the mature 34-amino acid, gastrin-34. Serum gastrin levels may also be elevated in gastric distention due to gastric outlet obstruction, and in a variety of conditions that lead to real or functional gastric hypo- or achlorhydria gastrin is secreted in an attempted compensatory response to achlorhydria. These include atrophic gastritis with or without pernicious anemia; a disorder characterized by destruction of acid-secreting (parietal) cells of the stomach, gastric dumping syndrome, and surgically excluded gastric antrum. Gastrinomas are usually found in the pancreas but they may be primary in the duodenum. A few cases in which a gastrinoma was primary in the stomach have been reported.
No special preparation is needed for Gastrin. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Gastrin. Your doctor depending on your condition will give specific instructions.
|All age groups
|< 100 pg/ml