Factor XIII is activated by thrombin in the presence of calcium. The primary function of activated factor XIII (XIIIa) is to catalyze the formation of covalent bonds between fibrin molecules stabilizing the fibrin clot. Factor XIII converts loosely hydrogen-bonded monomers into covalently bonded fibrin polymer. The resultant clot has increased tensile strength and is resistant to fibrinolysis. Factor XIII deficiency should be considered when a patient with excessive bleeding has both normal protime (PT) and activated partial thromboplastin time (aPTT).
No special preparation is needed for Factor XIII Assay. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Factor XIII Assay. Your doctor depending on your condition will give specific instructions.
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