Diagnostic Tests

Factor II Prothrombin Gene


Factor II Prothrombin Gene

Also known as Factor Ii Prothrombin Gene Gene Analysis Blood
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What is this test?

This is used to analyze the genes related to the formation of blood clots. In this test the blood sample of an individual is checked for genetic mutations/ changes in the blood clotting factor II, also called prothrombin. The prothrombin is a protein produced by the liver and plays a role in the blood clotting process.

What is prothrombin?

Prothrombin is a plasma protein which is produced by the liver. This protein is a precursor of thrombin. Prothrombin along with the all other blood clotting factors create a blood clotting cascade which is useful in preventing the excess of blood loss in an event of tissue damage due to either external or internal factors. Abnormalities or changes in the protein structure of prothrombin due to various factors may often lead to conditions like hemophilia(excessive bleeding) or Thrombophilia (Blood clotting disorders).

What is Thrombophilia?

Changes in the makeup of the protein prothrombin increase the occurrence of blood clots in deep veins. The increased frequency/ tendencies for the formation of blood clots in an individual is called thrombophilia and is known to be caused by various factors like the use of certain medicines, Genetic mutations of the prothrombin (Factor II), Factor V Leiden, increased levels of homocysteine, and various other factors like smoking, cancers, hormone therapy, pregnancy, heart, liver, and kidney diseases etc.

Why is this test performed?

This test is used to diagnose and estimate the risk of blood clotting disorders in pregnant women, people who have undergone major surgeries, individuals with cancer, individuals on certain medicines, and to diagnose the risk of thrombophilia in suspected members of a family.

Test Preparation

Inform your doctor if you are on any medications, have any allergies or underlying medical conditions before your Factor II Prothrombin Gene. Your doctor will give specific instructions depending on your condition on how to prepare for Factor II Prothrombin Gene.

No specific preparation is required for this test.

Understanding your test results

The normal test results may vary depending on age, health history, medical condition, etc.

The negative test results indicate the absence of the gene mutation of the prothrombin.

If your test results show positive it may indicate that you may have a genetic mutation of prothrombin which is increasing your risk of formation of blood clots.

If you get abnormal test results, consult your doctor immediately with your lab test reports.

GenderAge groupsValue
FEMALEAll age groupsGene mutated in positive cases
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