Human bone is continuously remodeled through a process of osteoclast-mediated bone formation and resorption. This process can be monitored by measuring serum and urine markers of bone formation and resorption. Approximately 90% of the organic matrix of bone is type I collagen, a helical protein that is cross-linked at the N- and C-terminal ends of the molecule. The amino acid sequences and orientation of the cross-linked alpha 2 N-telopeptide of type 1 collagen make it a specific marker of human bone resorption. N-terminal telopeptide (NTx) molecules are mobilized from bone by osteoclasts and subsequently excreted in the urine. Elevated levels of NTx indicate increased bone resorption.
No special preparation is needed for Collagen Type 1 Cross Linked N - Telopeptide Ntx Radioimmunoassay Random Urine. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Collagen Type 1 Cross Linked N - Telopeptide Ntx Radioimmunoassay Random Urine. Your doctor depending on your condition will give specific instructions.
|MALE||All age groups||21 - 66 nmol of bone collagen equivalents/mmol creatinine|
|FEMALE||All age groups||19 - 63 nmol of bone collagen equivalents/mmol creatinine|