Chromosome Analysis Points Of Contraception Karyotyping Blood

Chromosome Analysis Points of Contraception Karyotyping Blood is used to analyze the blood sample of a miscarried fetus for identifying whether the miscarriage was caused due to any abnormalities or deformities associated with chromosome disorders. This test is useful in planning pregnancy. This test is accurate and has a low rate of false positive results.

What are chromosomes?

Chromosomes contain the information (genes) regarding the growth and development of an organism. The chromosomes are the condensed form of DNA (Deoxyribonucleic acid) of an organism. Humans contain 46 chromosomes which are arranged in 23 pairs. Reproductive cells like sperm and egg in an individual contain 23 chromosomes which passed from the parent to the child.

The change in the number or arrangement in the chromosomes in an individual leads to the occurrence of various genetic diseases or disorders. Chromosome abnormalities can occur as duplication(extra chromosome) which can be called as trisomy(3) or tetrasomy(4) like Edward’s syndrome (condition in which the baby suffers from severe developmental delays due to an extra chromosome 18), Patau syndrome (a condition that cause intellectual disability and physical abnormalities due to the presence of an extra chromosome 13), Down’s syndrome (the genetic disorder which causes developmental and intellectual delays due to the presence of chromosome 21), other chromosomal abnormalities include presence of an extra X or Y which play a role in the determination of the sex of an individual, deletion (absence of a part or a fragment of a chromosome) and translocations( misarrangement of certain genes).

What is contraception karyotyping?

The process of examining the chromosomes in the obtained sample of cells/tissue is called karyotyping. This can be done using different methods which include microarray, FISH technique, etc. Contraception karyotyping is the procedure in which a small sample of tissue either fetal/amniotic fluid/blood/chorionic villi is collected and the chromosomes are analyzed to rule out whether the loss of pregnancy is due the changes in the chromosomes/abnormalities in the gene arrangements etc. This test is beneficial for planning the pregnancy accordingly, to prevent recurrence of miscarriages, loss of pregnancy, child deformities, etc.

Why this test is recommended?

This test is recommended for people/couples planning pregnancy, couples who have experienced frequent miscarriages (sudden loss of pregnancy), If you have a family history or high risk of inherited disease or chromosomal abnormalities, you may also be advised to perform this test before undergoing assisted reproduction treatment(In-Vitro Fertilisation) IVF, IUI (Intra-uterine insemination), etc.

Positive test results indicate that the loss of pregnancy is due to the presence of chromosomal abnormalities.

Negative test results indicate the absence of chromosomal abnormalities and the cause of the loss of pregnancy may be due to other reasons or conditions.

Based on the test results your doctor would be able to advise regarding the planning for pregnancy or further diagnostic tests.