CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. It binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
No special preparation is needed for Cd 58 Immunohistochemistry Bone Marrow. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Cd 58 Immunohistochemistry Bone Marrow. Your doctor depending on your condition will give specific instructions.
|All age groups
|Test is positive if the conditions listed are detected