CD57 is a 110-kD glycoprotein that is selectively expressed on natural killer cells and a subset of follicular T helper cells. Antibodies to CD57 also stain the myelin sheaths of central and peripheral nervous system cells. In normal tonsil, CD57 will stain a minor population of lymphocytes in the germinal centers. It is immunoreactive in tumors of neuroectodermal origins such as small cell carcinoma of the lung and carcinoid tumors, and is positive in adenocarcinomas of the prostate as well as normal and hyperplastic prostatic epithelium. Increased numbers of CD57-positive T cells are present in the background of lymphocyte-predominant Hodgkin lymphoma. The CD57 is expressed on both natural killer (NK) cells and T lymphocytes. The CD57 test measures CD57 positive NK cells only. The test is performed on EDTA whole blood. In patients with low CD 57 counts, Lyme disease and Chlamydophila pneumoniae infections should be included in differential diagnosis.
No special preparation is needed for Cd 57 Immunohistochemistry Biopsy Tissue. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Cd 57 Immunohistochemistry Biopsy Tissue. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|