The CD41 molecule is the integrin alphaIIb also known as platelet GPIIb. CD41 non-covalently associates with betaIII integrin (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. This antibody blocks platelet aggregation. CD41 completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes. The GPIIb/IIIa may be absent or strongly reduced in Glanzmann
No special preparation is needed for Cd 41A Immunohistochemistry Biopsy Tissue. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Cd 41A Immunohistochemistry Biopsy Tissue. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|