CD34 is 115-kD membrane-associated antigen found on human hematopoietic progenitor cells and vascular endothelial cells. In normal tonsil sections, antibodies to CD34 strongly stain vascular endothelial cells. Diagnostically, CD34 is used as a marker of immaturity in the setting of acute myeloid leukemia or B cell lymphoblastic leukemia. It is also useful in the classification of spindle cell neoplasms gastrointestinal stromal tumors, solitary fibrous tumors, and angiosarcomas are often positive. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. An essential prerequisite for successful procurement of sufficient autologous peripheral blood progenitor cells (PBPC) for engraftment is the optimal timing of collection.
No special preparation is needed for CD 34. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing CD 34. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the condition listed are detected|