Cd 3 Immunohistochemistry Bone Marrow

This test is used to find the presence of CD-3 cells in the bone marrow.

CD-3 is a cluster of proteins that is involved directly with the immunity of an individual. It helps in the development of T-cell and its survival. It is expressed on T-cells in the bone marrow, thymus, peripheral lymphoid tissue, and blood. It is the most commonly used marker for the identification of T-cell and any T-cell derived malignancies (cancer).

What are T-cells?

T-cells are a type of white blood cells that play a major role in the immunity of the body. They help in killing body cells infected with viruses or bacteria. They are also responsible for killing or eradicating cancerous cells in the body. They may stimulate other cells in the body to produce antibodies which are responsible for fighting microorganisms (viruses and bacteria). They may also remember a microorganism encountered by them throughout the lifetime of an individual. T-cells may also be responsible for the rejection of an organ transplant and may play a role in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, etc.

Why this test is performed?

Immunohistochemistry is a technique used for detecting specific molecules on cells. This test uses antibodies which specifically match with CD3 to detect the presence of CD3 on T-cells in the bone marrow. This test may be recommended to assess the individual’s immune system. It may also be recommended along with other tests to confirm the diagnosis of some cancers like lymphomas, autoimmune disorders like celiac disease, etc. It may also be used to assess the immune status of a patient suffering from an HIV infection as well as to determine the effectiveness of HIV treatment or cancer treatment.

If you have symptoms such as tiredness, cough, fever, stomach pain, enlarged spleen, sweating at night, shortness of breath, itching, rashes, bone pain, unexplained weight loss, pain while drinking alcohol, etc, your doctor may advise you to undergo this test.

Precautions:

Some medicines such as immunosuppressive drugs (tacrolimus, cyclosporine, etc.) may interfere with the test results. Hence, you are advised to inform about your medical conditions as well as your current medications to your doctor before undergoing this test.

The normal test results may vary depending on gender, age, health history, etc. There are no specific guidelines to interpret the test results. Hence, it is advisable to consult your doctor with regard to further diagnosis or medical intervention.