CD25 is the receptor for IL2 and is expressed on activated T cells, B cells, and macrophages. It will stain only scattered cells in normal tonsil. CD25 is expressed in certain types of B-cell lymphoma (hairy cell leukemia) and T-cell lymphoma (adult T-cell lymphoma/leukemia ATLL). An anti-CD25 therapy can be used in patients who have lymphomas that express CD25. CD25 antigen, the alpha subunit of interleukin-2 receptor, is a single-chain glycoprotein with a molecular weight of 55 kD. Following the activation of T cells interleukin-2 (IL-2) is rapidly synthesized and secreted. In response to this a subpopulation of T cells expresses high affinity receptors for IL-2. These cells proliferate, expanding the T cell population which is capable of mediating helper, suppressor and cytotoxic functions. IL-2 receptor is not exclusively found on T cells, and is reported to be expressed on HTLV-transformed T and B cells, EBV-transformed B cells, myeloid precursors and oligodendrocytes. It is absent on thymocytes, resting T cells, non-activated B cells and null cells. IL-2 receptor expression is reported to be associated with inflammatory and malignant conditions, lymphoid neoplasia, auto-immune diseases and allograft rejection.
No special preparation is needed for CD 25 Count Immunohistochemistry Bone Marrow. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing CD 25 Count Immunohistochemistry Bone Marrow. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|