CD23 strongly stains the cytoplasm and membranes of follicular dendritic cells and the membranes of a subset of follicular mantle zone B-lymphocytes. Typically, B-cell small lymphocytic lymphoma/chronic lymphocytic leukemias are CD5 positive and CD23 positive, while mantle cell lymphoma is CD5 positive and CD23 negative. Antibodies to CD23 are diagnostically useful in the classification of low-grade B-cell lymphomas. The leukocyte antigen CD23 is expressed during B-cell development, and functions as an IgE receptor and a lymphocyte growth factor. The antigen was demonstrated in four of the B-cell and one of the T-cell tumours. CD23 may be important in mediating the mixed cellular infiltrate characteristic of Hodgkin's lymphoma.
No special preparation is needed for CD 23 Count Immunohistochemistry Biopsy Tissue. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing CD 23 Count Immunohistochemistry Biopsy Tissue. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|