CD16 is known as low affinity IgG receptor III (Fc_RIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (Fc_RIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (Fc_RIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).
No special preparation is needed for IHC Marker CD 16 Flow Cytometry Bone Marrow. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing IHC Marker CD 16 Flow Cytometry Bone Marrow. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|