Cd 14 Immunohistochemistry Biopsy Tissue

CD14 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein that is preferentially expressed by mature cells of monocytic lineage (monocytes, macrophages, Langerhans cells) and on follicular dendritic cells. Lower levels of expression are observed on neutrophils. CD14 is important for the recognition and clearance of bacterial lipopolysaccharides and apoptotic cells. This immunostain may be useful as a marker of histiocytic and monocytic lineage in acute leukemias. CD14 is a marker of terminally differentiated monocytes and macrophages and can be used along with lysozyme and CD163 to separate histiocytic tumors from other epithelioid malignancies. CD14 is a membrane-associated glycosylphosphatidylinositol-linked protein expressed at the surface of cells, especially macrophages. CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.