In normal lymphoid tissues, CD123 is expressed in plasmacytoid monocytes and mast cells in interfollicular regions. In bone marrow, it is expressed in hematopoietic precursors, mast cells, and megakaryocytes. CD123 is part of the IL3 receptor complex, involved in cellular growth and differentiation. Certain reactive lymph nodes show increased numbers of plasmacytoid monocytes, eg, Kikuchi lymphadenitis. CD123 is characteristically expressed in blastic plasmacytoid dendritic cell neoplasm, aiding in its distinction from acute monocytic leukemia. CD123 is highly expressed in normal plasmacytoid dendritic cells and in the plasmacytoid dendritic cell neoplasm (also known as hematodermic tumor). Among lymphoproliferative disorders, CD123 expression is largely limited to hairy cell leukemia.
No special preparation is needed for CD 123. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing CD 123. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|