CD11c is a member of the leukocyte specific integrin family, involved in adherence to activated endothelial cells and complement-mediated phagocytosis. CD11c is normally expressed on histiocytes and monocytes, and weakly expressed on granulocytes. CD11c is also expressed on certain B cell neoplasms, including hairy cell leukemia and splenic marginal zone lymphoma. Found on Monocytes and Granulocytes. Associated with Hairy cell leukemia; Marginal zone lymphoma; some other B-cell neoplasms; some AML. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
No special preparation is needed for IHC Marker CD 11c Immunohistochemistry Biopsy Tissue. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing IHC Marker CD 11c Immunohistochemistry Biopsy Tissue. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|