Afb Mtb - Cycloserine Antibiotic Sensitivity Sputum

Mycobacterium species that cause tuberculosis and leprosy exhibit its acid - fastness due to the high mycolic acid content in its cell walls which forms a staining pattern due to low absorption and high retention. The AFB Susceptibility Cycloserine test is a way of measuring or detecting the sensitivity in a given sample of sputum towards cycloserine. It helps in detecting the presence of drugs resistant to Tuberculosis or Leprosy. Preparation for AFB Susceptibility - Cycloserine Test - Used as part of a combination approach in multidrug-resistant tuberculosis. Central nervous system toxicity has been observed in the early phase of treatment and is associated with high peak plasma concentrations as a result of renal impairment. MycoTB MIC plate were the only methods that yielded second-line susceptibilities and revealed significant quantitative correlations for all drugs except cycloserine, as well as moderate to excellent kappa coefficients for all drugs except for para-aminosalicylic acid. In summary, the performance of M. tuberculosis susceptibility testing differs by platform and by drug. Cycloserine is only marginally active against M. tuberculosis, and is primarily used for the treatment of MDR-TB. The use of cycloserine is limited due to its weak activity and frequent adverse reactions.