Afb Isolation Rapid Culture Endometrial Biopsy Tissue

Tuberculosis is a chronic, granulomatous disease caused by M. tuberculosis. Identification, and, if appropriate, antibiotic sensitivity, is required to initiate necessary therapy. Endometrial tuberculosis is an important cause of female infertility. Endometrial tuberculosis is almost invariably secondary to a primary lesion elsewhere in the body. In the majority, the infection reaches the endometrium by the haematogenous route where it either persists in the basal layer, which is not shed during menstruation, or it gets reinfected from the tubes following menstruation. Most women with endometrial tuberculosis are asymptomatic and present with infertility. Diagnosis of endometrial tuberculosis remains a difficult task. The direct demonstration of Mycobacterium tuberculosis in endometrial samples has very low sensitivity because most lesions are paucibacillary. Though endometrial sample obtained by curettage is considered the ideal sample for testing for endometrial tuberculosis, interventional procedures like curettage can further lead to flaring of the existing pathology hence testing of menstrual blood was proposed as a potential less invasive sample which could be easily obtained in asymptomatic cases presenting with infertility. Any method that is used to diagnose endometrial tuberculosis should be highly sensitive to diagnose the disease reliably in its early stage, so that treatment may improve the prospects of cure before the tubes are damaged beyond recovery