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ADA CSF

Also known as Adenosine Deaminase Csf
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What is this test?

This test is used to analyze the level of adenosine deaminase enzyme present in the cerebrospinal fluid of an individual. This test is useful in differentiating between tubercular meningitis and non-tubercular meningitis. Early detection of tubercular meningitis in individuals increases the chances of successful and effective treatment.

What is Adenosine Deaminase?

Adenosine deaminase is an enzyme which plays a role in the conversion of adenosine to inosine during purine metabolism. The enzyme breaks down the adenosine present in food and for the synthesis of nucleic acids within cells. It also plays a role in the development and maintenance of immunity within the body. The enzyme stimulates the release of immune cells in the presence of bacterial, viral or other infective agents. Absence of adenosine deaminase enzyme may prevent the formation of immune cells (T-Lymphocytes, B-Lymphocytes) which leads to reduced immunity and increased sensitivity to bacterial and viral infections.

What is Tuberculosis?

Tuberculosis TB is a bacterial infection caused by Mycobacterium tuberculosis MTB. Generally, TB affects the lungs and sometimes it can also affect other organs and parts of the body. MTB is airborne and can spread through the air from one person to another. Individuals who are suffering from TB may experience symptoms such as cough which lasts more than 2-3 weeks, cough with blood, chest pain, difficulty in breathing, weight loss, fever, night sweats, etc.

Why is this test recommended?

This test is recommended when you may experience certain symptoms like difficulty in breathing, headache, stiffness of the neck, blurred vision, chest pain or pressure, weakness, dizziness, swelling, and painful joints, etc.

This test can also be recommended by the doctor if you had suffered from diseases like tuberculosis, bacterial or viral meningitis, leukemia (cancer which affects the blood and bone marrow), autoimmune diseases, or any other similar illnesses in the past.

Test Preparation

Inform your doctor if you are on any medications, have any allergies or underlying medical conditions before your ADA CSF. Your doctor will give specific instructions depending on your condition on how to prepare for ADA CSF.

Understanding your test results

Higher levels of adenosine deaminase in the blood may indicate the presence of tuberculosis. High levels of ADA(Adenosine deaminase) in blood in non-tubercular patients may indicate that the individual may have any autoimmune disorders, cancer or any other diseases/disorders.

Based on the test results, your doctor may advise you appropriate medical treatments, lifestyle modifications, or further diagnostic tests, etc.

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