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Activated Protein C Resistance Genotyping Blood

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Activated Protein C Resistance Genotyping Blood

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What is this test?

Activated Protein C Resistance Genotyping Blood Test helps to assess a single point mutation in the factor V gene which can be a reason for protein C Resistance. This test helps to determine activated protein C-resistance and evaluate inappropriate clot formation in the blood.

What is Protein C Resistance?

Protein C is one among two proteins in the blood that regulates the clot formation in the blood. Normally, in case of an injury in order to stop the bleeding small cell fragments called platelets and clotting factors aggregate to form a plug at the injury site. This clot which is formed will prevent the blood loss and remains in place until the injury has healed. It is then broken down once the injury has healed.

Protein C helps to control the blood clot formation by inactivating specific coagulation factors (factors V and VIII) that are necessary to form blood clots. If there are not enough Protein S in the blood, it may lead to excessive clotting.

Genetic defects of Protein C is a major cause of inappropriate blood clotting. Inherited resistance to activated protein C is another major risk factor for inappropriate blood clotting. This resistance happens when there is a single point mutation in the factor V gene. The mutation that occurs is a substitution of an arginine at position 506 by glutamine. The impaired inactivation of mutated factor V by the activated protein C lead to inappropriate blood clotting.

Activated protein C-resistance is not very common in individuals with deficiency of protein S (a protein involved in the clotting process), protein C or antithrombin III (another protein involved in the clotting process). However, individuals with combined defects are at more risk of developing inappropriate blood clotting than compared to individuals with single defects.

Why this test is performed?

This test is performed to determine whether you have activated protein C-resistance or to evaluate inappropriate blood clotting. Your doctor may ask to perform this test in case if you have any clotting disorders or had an unexplained blood clot. This test is also performed if you have a family history of protein C deficiency disorders to check whether you have combined defects (protein C deficiency disorders and activated protein C-resistance).

How often this test is performed?

If you have a family history of inherited protein C deficiencies or clotting disorders your doctor may ask to perform this test in a 6 monthly or a yearly basis. If you are diagnosed with inherited protein C deficiencies or clotting disorders, then you may have to perform this test on a regular basis as instructed by the doctor.

Also known as Activated Protein C Resistance.

Test Preparation

Inform your doctor if you are on any medications, have any allergies or underlying medical conditions before your Activated Protein C Resistance Genotyping Blood. Your doctor will give specific instructions depending on your condition on how to prepare for Activated Protein C Resistance Genotyping Blood.

No special preparation is necessary for this test. You may have to wait at least 10 days after an inappropriate blood clotting episode and stop taking oral warfarin anticoagulant therapy for two weeks prior to the test. However, follow all the instructions given by your healthcare provider.

Understanding your test results

Individuals with activated protein C-resistance may have inappropriate blood clotting or are at risk of developing inappropriate blood clotting.

Individuals with activated protein C-resistance and protein C deficiency disorders (combined defects) are at more risk of developing inappropriate blood clotting or thrombosis (clotting disorder).

Based on the test results, your doctor may advise appropriate medical treatments or further diagnostic tests.

GenderAge groupsValue
UNISEXAll age groups5mcg/ml
UNISEXAll age groups> 2.1
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