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Zenflox 400 MG Tablet SR
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Zenflox 400 MG Tablet SR

Manufactured byMankind Pharmaceuticals Ltd.
ContainsOfloxacin
Description
Zenflox 400 MG Tablet SR is fluoroquinolone antibiotic used for the treatment of bacterial infections that affect the nose, throat, eyes, ears, skin, lungs, or urinary tract. This medicine is effective against a large number of bacteria. It kills or prevents the growth of bacteria in the body. It is not effective against infections caused by viruses. Common side effects of Zenflox 400 MG Tablet SR are diarrhoea, stomach pain, headache, weakness, nausea, and vomiting. Zenflox 400 MG Tablet SR can cause muscle damage, usually in the ankle. Zenflox 400 MG Tablet SR should only be used to treat or prevent infections that are caused by bacteria. Zenflox 400 MG Tablet SR is available on prescription as tablets, injection, syrup, suspension, eye drops and eye/ear drops. Once an antibiotic is started, it is always recommended to finish the entire course of treatment. For the best results, take this antibiotic at evenly spaced times. You can take Zenflox 400 MG Tablet SR with or without food. For the ease of remembering, take Zenflox 400 MG Tablet SR around the same time every day.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Zenflox 400 MG Tablet SR

  • Nausea and vomiting
  • Headache
  • Loose stools
  • Stomach pain
  • Muscle pain
  • Change in taste
  • Painful urination
  • Dry mouth
  • Joint pain
  • Excessive air or gas in stomach
  • Runny Nose
  • Loss of appetite
  • Skin rash

Uses of Zenflox 400 MG Tablet SR

What is it prescribed for?

  • Urinary Tract Infection
  • Pyelonephriits
  • Urethritis
  • Cystitis
  • Community-Acquired Pneumonia
  • Bronchitis
  • Prostatitis
  • Skin and soft tissue infections
  • Gonococcal infection
  • Pelvic Inflammatory Disease
  • Bacterial conjunctivitis
  • Otitis Externa
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    You will start to feel better in 2 to 3 days after taking Zenflox 400 MG Tablet SR. But finish your entire course of treatment, even if the condition gets better.
  • How long do the effects of this medicine last?
    The effect of Zenflox 400 MG Tablet SR lasts for about 12 hours and then you may have to take your next dose as directed by your doctor/pharmacist.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Zenflox 400 MG Tablet SR.
  • Can this medicine be taken during pregnancy?
    Zenflox 400 MG Tablet SR should be avoided during pregnancy due to the risk of adverse effects on the baby's developing joints. Zenflox 400 MG Tablet SR is not known to cause harmful effects on the baby if is taken later in pregnancy. Take Zenflox 400 MG Tablet SR only upon your doctor's recommendation.
  • Can this medicine be taken while breast-feeding?
    Zenflox 400 MG Tablet SR is not known to be harmful in breastfeeding women. It passes into breast milk in small amounts. Hence it is acceptable in nursing mothers upon your doctor's recommendation. Baby should be observed for symptoms such as diarrhoea and yeast infection.

Allergy

Avoid taking Zenflox 400 MG Tablet SR if you are previously allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Tendinitis

Zenflox 400 MG Tablet SR can cause muscle damage especially in old age. Do not use Zenflox 400 MG Tablet SR if you have tendonitis (swelling of fibres that attach bone with muscles) or tendon rupture (a partial or complete tear of the tendon- the tissue that connects muscle to bone).

Myasthenia gravis

Myasthenia gravis is a skeletal muscle weakness condition characterized by severe weakness of any of the muscles under your voluntary control, including the arms and legs. Zenflox 400 MG Tablet SR should be avoided in patients with myasthenia gravis since it may get worsen.
Warnings for special population

Pregnancy

Zenflox 400 MG Tablet SR should be avoided during pregnancy due to the risk of adverse effects on the baby's developing joints. Zenflox 400 MG Tablet SR is not known to cause harmful effects on the baby if is taken later in pregnancy. Take Zenflox 400 MG Tablet SR only upon your doctor's recommendation.

Breast-feeding

Zenflox 400 MG Tablet SR is not known to be harmful in breastfeeding women. It passes into breast milk in small amounts. Hence it is acceptable in nursing mothers upon your doctor's recommendation. Baby should be observed for symptoms such as diarrhoea and yeast infection.
General warnings

Muscle damage

Zenflox 400 MG Tablet SR can cause muscle damage usually on the tendons that surround the ankle. Inform your doctor if you feel pain, numbness, or tingling sensations in your muscles.

Antibiotic resistance

Finish your entire course of treatment with Zenflox 400 MG Tablet SR, even if the condition gets better to avoid antibiotic resistance (the bacteria may become resistant to antibiotics). If you still feel unwell after completing your antibiotic course, make an appointment to consult your doctor.

Driving or operating machinery

Zenflox 400 MG Tablet SR may cause dizziness or sleepiness and interfere with eyesight. Hence do not drive a vehicle or operate machinery after taking this medicine.

Photosensitivity

Zenflox 400 MG Tablet SR may make you more sensitive to sunlight or tanning lights. Use sunscreens or wear protective clothing to avoid adverse reactions before stepping outside.

Diarrhoea

Zenflox 400 MG Tablet SR can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe diarrhoea that is watery or bloody. Call your pharmacist/doctor before taking anti-diarrhoeal medication.

Antacids

If you are taking an antacid containing aluminium and magnesium salts for indigestion, it can increase the time it takes for Zenflox 400 MG Tablet SR to act on your body. Because of this, it is recommended to take this antibiotic at least 1 hour before or 2 hours after taking antacids.

Missed Dose

Try not to skip a dose of Zenflox 400 MG Tablet SR. And if a dose is skipped, do not add it up to the next dose.

Overdose

Seek emergency medical attention in case of an overdose with Zenflox 400 MG Tablet SR.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Escitalopram

Ethinyl Estradiol

Corticosteroids

Quinidine

Aspirin

Disease interactions

Central nervous system disorders

Use Zenflox 400 MG Tablet SR with caution in patients with nerve problems, seizures, depression, and psychotic reactions. Zenflox 400 MG Tablet SR can trigger these conditions and inform your doctor immediately if these reactions occur.

Colitis

Use Zenflox 400 MG Tablet SR with extreme caution in patients with gastrointestinal (mouth to anus) diseases, particularly colitis (swelling of the inner lining of the colon), since it may worsen the patient's condition.

QT Prolongation

Zenflox 400 MG Tablet SR may cause heart rhythm problem called prolonged QT intervals (an electrical heartbeat disturbance) in some patients who are taking heart medications. It may result in fast, rapid, and irregular heartbeats.

Kidney Disease

Patients with kidney diseases need special consideration while taking Zenflox 400 MG Tablet SR due to the risk of kidney damage. Dose adjustment should be done based on the clinical condition.
Food interactions
Avoid using Zenflox 400 MG Tablet SR along with multivitamins with minerals. If needed it is suggested to use before 2 to 4 hours of taking multivitamins with minerals or after 4 to 6 hours of taking multivitamins with minerals.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Oral forms: Take Zenflox 400 MG Tablet SR as instructed by the doctor. Never take more than the prescribed dose. Take Zenflox 400 MG Tablet SR at around the same time daily. Do not give your medicine to other people even if their condition appears to be the same as yours. Injection: Zenflox 400 MG Tablet SR should be administered by a qualified healthcare professional in a clinic or hospital. Topical forms: Use Zenflox 400 MG Tablet SR as directed by the doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Zenflox 400 MG Tablet SR stops the action of a bacterial enzyme called DNA-gyrase. This helps to kill or prevent the growth of bacteria in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Fluoroquinolones, Antibiotics

Schedule

Schedule H

Drugs, H., 2021. Ofloxacin: Medlineplus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 6 January 2021].

https://medlineplus.gov/druginfo/meds/a691005.html>

Medicines.org.uk. 2021. Ofloxacin 200 Mg Tablets - Patient Information Leaflet (PIL) - (Emc). [online] Available at: < [Accessed 6 January 2021].

https://www.medicines.org.uk/emc/product/8481/pil>

Go.drugbank.com. 2021. Ofloxacin | DrugBank Online. [online] Available at: < [Accessed 28 January 2021].

https://go.drugbank.com/drugs/DB01165>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 6 January 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/019735s059lbl.pdf>

Pubchem.ncbi.nlm.nih.gov. 2021. Ofloxacin. [online] Available at: < [Accessed 28 January 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Ofloxacin>
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Information on this page was last updated on 29 Jan 2021

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