Ofloxacin

Description

Ofloxacin is a broad-spectrum antibiotic used to treat a variety of conditions such as bronchitis, pneumonia, gonococcal infection, and certain types of infectious diarrhea. This medicine is not recommended for use in cases of common cold, flu or other viral infections since it is active only against infections caused by bacteria. Caution is advised while using this medicine in the elderly population since it increases the risk of tendinitis and tendon rupture.

Side effects

Major & minor side effects for Ofloxacin

  • Abdominal pain
  • Anxiety
  • Black or tarry stools
  • Confusion
  • Diarrhea
  • Fever
  • Painful urination
  • Decreased appetite
  • Joint pain
  • Change in taste
  • Excessive air or gas in stomach
  • Runny Nose

Uses of Ofloxacin

What is it prescribed for?

  • Cystitis
  • Pyelonephritis
  • Urethritis
  • Skin and Structure Infection
  • Pneumonia
  • Bronchitis
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 to 3 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 16 to 20 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary since it may affect the development of the infant's joints. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects such as diarrhea or diaper rash.

Allergy

This medicine is not recommended for use in patients with a known allergy to Ofloxacin or any other fluoroquinolones.

Tendinitis or tendon rupture

This medicine is not recommended for use in patients with a history of tendon rupture or tendinitis (a condition in which the tissue connecting muscle to the bone becomes inflamed) since it may worsen the patient's condition.

Myasthenia gravis

This medicine is not recommended for use in patients with a history of myasthenia gravis since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary since it may affect the development of the infant's joints. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects such as diarrhea or diaper rash.
General warnings

Tendinitis and Tendon ruputure

Use of Ofloxacin will increase the risk of developing tendinitis or tendon rupture during the treatment or several months after the treatment. This may affect your shoulders, hands, ankles, or other parts of your body. You are at a higher risk if you are more than 60 years of age or if you have undergone a transplant of kidney, heart, or lung. You are also at a higher risk if you are on corticosteroids like dexamethasone, methylprednisolone, or prednisone. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Drug-resistance

Usage of Ofloxacin without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing benefits and may even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Choice of treatment

Ofloxacin can be used to treat acute bacterial exacerbation of chronic bronchitis or uncomplicated cystitis, but only as a last resort. This drug should be used only if you have no alternative treatment options for the above-mentioned conditions.

Drowsiness

Ofloxacin may cause dizziness or sleepiness and interfere with eyesight. Hence it is advised not to drive vehicles and operate heavy machinery after taking this medicine.

Photosensitivity

This medicine may make you more sensitive to sunlight or tanning lights. You are advised to use sunscreen and wear protective clothing to avoid adverse reactions to sunlight during treatment with this medicine.

Missed Dose

Oral forms: The missed dose of Ofloxacin should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not double the dose to make up for the missed dose. Since Ofloxacin injection is mostly administered by a healthcare professional in the clinical or hospital setting, the likelihood of missing a dose is very low.

Overdose

Oral forms: Seek emergency medical treatment or contact your doctor in case of an overdose. Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Escitalopram

Ethinyl Estradiol

Corticosteroids

Quinidine

Aspirin

Antidiabetic drugs

Disease interactions

Central nervous system disorders

This medicine should be used with extreme caution in patients with a history of seizure disorder and other central nervous system abnormalities since it may worsen the patient's condition. Report any incidence of tremors, restlessness, anxiety, confusion, hallucinations, etc., to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Colitis

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

QT Prolongation

This medicine should be used with extreme caution in patients with a history of QT prolongation due to the increased risk of worsening of the patient's condition. This risk is especially higher in patients with heart diseases or electrolyte disturbances and elderly patients. Report any incidence of discomfort in the chest, heart palpitations, etc., to the doctor on priority. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney Disease

Ofloxacin should be used with caution in patients with renal diseases due to the increased risk of severe adverse effects. Report any unusual symptoms to the doctor immediately. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Ofloxacin with or without food. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Ofloxacin works by inhibiting an enzyme required for the bacterial DNA to replicate, thus inhibiting bacterial cell division.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Quinolones

Schedule

Schedule H

Ofloxacin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 17 February 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a691005.html

[Internet]. 2017 [cited 17 February 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/25497#PRODUCTINFO

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 17 February 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

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Information on this page was last updated on 20 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.