Themiset 75 mcg Injection

Manufactured byTHEMIS MEDICARE LTD
ContainsPalonosetron
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Description

Themiset 75 mcg Injection is an antiemetic drug used to prevent nausea and vomiting associated with cancer chemotherapy. It works by blocking the action of a natural substance that causes nausea and vomiting. This medicine is usually given 30 to 60 minutes prior to the start of chemotherapy.

Substitutes

List of substitutes for Themiset 75 mcg Injection

Side effects

Major & minor side effects for Themiset 75 mcg Injection

  • Headache
  • Difficulty with bowel movements
  • Dry mouth
  • Chills
  • Blurred vision
  • Difficulty in breathing
  • Chest discomfort
  • Dizziness

Uses of Themiset 75 mcg Injection

What is it prescribed for?

  • Chemotherapy induced nausea and vomiting
  • Post operative nausea and vomiting
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Concerns

Commonly asked questions

  • Onset of action
    Following oral administration, the effect of this medicine is observed within 60 minutes. Following IV administration, the effect of this medicine is observed with 30 minutes.
  • Duration of effect
    The effect of this medicine lasts for the maximum duration of 7 days.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to palonosetron or any other inactive ingredients present along with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.
General warnings

Pediatric dose

This medicine is not recommended for use in patients below 18 years of age for prevention of postoperative nausea and vomiting since the safety and efficacy of use for this indication are not clinically established.

Missed Dose

Since this medicine is usually administered in the clinical/hospital setting, the likelihood of missing a dose is very low.

Overdose

Since this medicine is usually administered in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clozapine

Tacrolimus

Dextromethorphan

Disease interactions

Renal impairment

This medicine should be used with caution in patients with renal impairment due to the increased risk of severe adverse effects. Close monitoring of renal function, appropriate dose adjustments, or replacement with suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Carefully follow all the instructions given by your doctor and take/use Themiset 75 mcg Injection exactly as directed. Report any unusual symptoms to the doctor immediately.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine blocks the action of certain natural substances that can trigger nausea and vomiting.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antiemetics, 5HT3 receptor antagonists

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 10 January 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021372s018s019lbl.pdf

Palonosetron - DrugBank [Internet]. Drugbank.ca. 2018 [cited 10 January 2018]. Available from:

https://www.drugbank.ca/drugs/DB00377

Palonosetron Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 10 January 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a610002.html

[Internet]. 2018 [cited 10 January 2018]. Available from:

https://www.medicines.org.uk/emc/product/513

DailyMed -palonosetron hydrochloride injection [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 10 January 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4216772-6c37-4ff0-a575-f758390656e3

[Internet]. Accessdata.fda.gov. 2018 [cited 21 February 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022233s005lbl.pdf
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