Palonosetron
Description
Palonosetron is an antiemetic drug used to prevent nausea and vomiting associated with cancer chemotherapy. It works by blocking the action of a natural substance that causes nausea and vomiting. This medicine is usually given 30 to 60 minutes prior to the start of chemotherapy.
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Side effects
Major & minor side effects for Palonosetron
- Headache
- Difficulty with bowel movements
- Dry mouth
- Chills
- Blurred vision
- Difficulty in breathing
- Chest discomfort
- Dizziness
Uses of Palonosetron
What is it prescribed for?
- Chemotherapy induced nausea and vomiting
- Post operative nausea and vomiting
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Concerns
Commonly asked questions
- Onset of actionFollowing oral administration, the effect of this medicine is observed within 60 minutes. Following IV administration, the effect of this medicine is observed with 30 minutes.
- Duration of effectThe effect of this medicine lasts for the maximum duration of 7 days.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit forming tendency has been reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to palonosetron or any other inactive ingredients present along with this medicine.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.
General warnings
Pediatric dose
This medicine is not recommended for use in patients below 18 years of age for prevention of postoperative nausea and vomiting since the safety and efficacy of use for this indication are not clinically established.
Missed Dose
Since this medicine is usually administered in the clinical/hospital setting, the likelihood of missing a dose is very low.
Overdose
Since this medicine is usually administered in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Clozapine
Tacrolimus
Dextromethorphan
Disease interactions
Renal impairment
This medicine should be used with caution in patients with renal impairment due to the increased risk of severe adverse effects. Close monitoring of renal function, appropriate dose adjustments, or replacement with suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Carefully follow all the instructions given by your doctor and take/use Palonosetron exactly as directed. Report any unusual symptoms to the doctor immediately.
Miscelleneous
How it works
This medicine blocks the action of certain natural substances that can trigger nausea and vomiting.
Legal Status
Classification
Category
Antiemetics, 5HT3 receptor antagonists
Schedule
Schedule H
[Internet]. Accessdata.fda.gov. 2018 [cited 10 January 2018]. Available from:
Palonosetron - DrugBank [Internet]. Drugbank.ca. 2018 [cited 10 January 2018]. Available from:
Palonosetron Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 10 January 2018]. Available from:
[Internet]. 2018 [cited 10 January 2018]. Available from:
DailyMed -palonosetron hydrochloride injection [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 10 January 2018]. Available from:
[Internet]. Accessdata.fda.gov. 2018 [cited 21 February 2018]. Available from:
Information on this page was last updated on 21 Feb 2018
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.