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Symbiotik XL (500/100 mg) Injection
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Symbiotik XL (500/100 mg) Injection

Manufactured byCadila Pharmaceuticals Ltd.
ContainsAmoxycillin (500 mg) + Clavulanic Acid (100 mg)
Description
Symbiotik XL (500/100 mg) Injection is a combination medicine used to treat a variety of bacterial infections. Amoxycillin interferes with the growth and division process of the bacterial cell wall while clavulanic acid ensures extended anti-bacterial activity. This combination is used to treat bacterial infections of the lungs and airways, middle ear, sinuses, skin, bone and joints, and the urinary tract.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Symbiotik XL (500/100 mg) Injection

  • Allergic Skin Reaction
  • Diarrhea
  • Fever
  • Joint pain
  • Skin yellowing
  • Easy bruising and bleeding
  • Heavy menstrual bleeding
  • Tooth discoloration
  • Nausea or vomiting
  • Altered sense of taste
  • Convulsions
  • Painful intercourse
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Black or tarry stools
  • Muscle or joint pain
  • Sleeplessness
  • Irregular heartbeat

Uses of Symbiotik XL (500/100 mg) Injection

What is it prescribed for?

  • Ear Infection (Otitis Media)
  • Nose Infection (Sinusitis)
  • Throat Infection (Tonsillitis/Pharyngitis)
  • Lower Respiratory Tract Infection
  • Skin Infection
  • Urinary Tract Infection
  • Infections associated with surgical procedures
  • Bone and joint infections
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1-2 hours of administration.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 6-8 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine should be used in pregnant women only if the need is clearly established and the benefits outweigh the risks. Consult your doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine should be used in breastfeeding women only if the need is clearly established. Consult your doctor before using this medicine.

Allergy

This medicine is not recommended for use if you have a known history of allergy to Amoxycillin or Clavulanic acid derivatives. Do not consume this medicine if you have a known history of allergy to Penicillins or Beta lactam antibiotics.

Cholestasis

This medicine is not recommended for use if you have had a condition where the normal flow of bile from the liver is interrupted (cholestasis).

Liver dysfunction

This medicine is not recommended for use if you have a history of liver dysfunction associated with the use of these medicines in combination.
Warnings for special population

Pregnancy

This medicine should be used in pregnant women only if the need is clearly established and the benefits outweigh the risks. Consult your doctor before using this medicine.

Breast-feeding

This medicine should be used in breastfeeding women only if the need is clearly established. Consult your doctor before using this medicine.
General warnings

Allergic Reaction

This medicine is likely to cause moderate to severe allergic reaction and the likelihood is very high in patients who are known to have an antibiotic allergy. Report the occurrence of any such reaction to the doctor on priority.

Diarrhea

Use of this medicine is likely to cause diarrhea. It may be a mild episode requiring no specific treatment or a severe case of colitis or Clostridium Difficile-Associated Diarrhea (CDAD). Chances of occurrence are very high in patients having a history of diarrhea after using antibiotics. All such instances should be reported to the doctor on priority.

Mononucleosis

This medicine is not recommended for use in patients with Mononucleosis. This medicine is likely to cause rashes and bumps on the skin if the patient is suffering from Mononucleosis.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Liver disease

This medicine should be used with caution in patients having an impairment of the normal liver function. It is advised to regularly monitor the liver enzyme levels while taking this medicine and even after treatment with this medicine is complete.

Form and method of administration

This medicine is generally administered either by slow intravenous injection over a period of 3-4 minutes or by intravenous infusion over a period of 30-40 minutes. It is not suitable for intramuscular administration. The patient should be shifted to oral forms as soon as possible.

Missed Dose

Since this medicine is administered in a clinical or a hospital setup, the likelihood of a missed dose is very low. Contact your doctor immediately if you have missed a scheduled dose of this medicine.

Overdose

Since this medicine is administered in a clinical or a hospital setup, the likelihood of an overdose is very low. However, if an overdose of this medicine is suspected, your doctor will initiate emergency medical treatment. Symptoms of an overdose may include nausea, vomiting, diarrhea, drowsiness, etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Doxycycline

Methotrexate

Warfarin

Ethinyl Estradiol

Live vaccines

Disease interactions

Mononucleosis

This medicine is not recommended for use in patients with a history of mononucleosis since these patients may develop a skin reaction/eruption. Replacement with a suitable alternative should be done under your doctor's supervision.

Colitis

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis. Inform your doctor if you have any history of gastrointestinal diseases. Report any incidence of severe diarrhea, abdominal pain, and blood in stools to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition.

Renal Diseases

This medicine should be used with caution in patients with a history of renal diseases or active renal diseases. Close monitoring of the renal function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions

Urine Sugar Test (Benedict's of Fehling's reagent)

Report the use of this medicine prior to the test. This medicine may give a false positive result for the presence of glucose/sugar in the urine. The urine sugar test should be performed with a different reagent in case you are receiving this medicine.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Administer Symbiotik XL (500/100 mg) Injection exactly as prescribed by the doctor. It is recommended to take this medicine under the supervision of a doctor or a trained healthcare professional.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Amoxycillin binds to certain specific receptors and prevents the formation of a necessary component for cell wall building process. Clavulanic acid is effective against a specific species of bacteria that are resistant to other antibiotic medicines. Thus, the combination becomes effective against an extended range of bacteria.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Beta-lactamase inhibitors, Aminopenicillins

Schedule

Schedule H

[Internet]. 2017 [cited 1 August 2017]. Available from:

http://www.medsafe.govt.nz/profs/Datasheet/a/Augmentininj.pdf

[Internet]. 2017 [cited 1 August 2017]. Available from:

http://www.pharmaline.co.il/images/newsletterregistration/gsk/18032011/augmentindr.pdf

Amoxicillin and Clavulanic Acid: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 1 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a685024.html

DailyMed - AMOXICILLAN AND CLAVULANATE POTASSIUM- amoxicillan and clavulanate potassium tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 1 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=909c85de-c076-4444-b63c-cd8bdc556f36

Clavulanate - DrugBank [Internet]. Drugbank.ca. 2017 [cited 16 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00766

Amoxicillin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 16 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB01060
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Information on this page was last updated on 29 Aug 2017

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