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Prepulsid 5 MG Tablet

Manufactured byJohnson & Johnson
ContainsCisapride
Description
Prepulsid 5 MG Tablet is used to increase the mobility of food in the stomach and intestine. It relieves the symptoms of nighttime heartburn in individuals who have not adequately responded to other medications. It is also used for the treatment of diseases like non-ulcer dyspepsia, gastro-intestinal reflux disease, etc. This medicine is banned for sale in India due to its severe cardiovascular side effects.

Side effects

Major & minor side effects for Prepulsid 5 MG Tablet

  • Irregular heartbeat
  • Difficulty in breathing
  • Headache
  • Nausea or vomiting
  • Joint pain
  • Blurred vision
  • Sleeplessnes

Uses of Prepulsid 5 MG Tablet

What is it prescribed for?

  • Non-ulcer dyspepsia
  • Gastroparesis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 30-60 minutes of administration.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 7-10 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known history of allergy to Cisapride or any other ingredient present along with the formulation.

Gastrointestinal haemorrhage

This medicine is not recommended for use in patients having internal bleeding of the stomach and intestine. This may be attributed to various reasons including a ruptured bowel (Gastrointestinal Perforation).

Mechanical bowel obstruction

This medicine is not recommended for use in patients having a blockage in the intestine.

Serious cardiac arrhythmias

This medicine is not recommended for use in patients with cardiac arrhythmias (irregular heartbeats) due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Use in elderly population

This medicine should be used with extreme caution in elderly patients above 65 years of age due to the risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bleeding of stomach and intestine

Report any instance indicating bleeding of the stomach like the presence of blood in stools, black or coffee-colored stools to the doctor immediately. This medicine should not be used if bleeding is evident or even suspected.

Mechanical obstruction of stomach

Report any incidence indicating intestinal blockage like severe bloating, nausea, vomiting, severe abdominal cramps, constipation, etc to the doctor. The use of this medicine is not recommended in such cases.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Cardiovascular effects

This medicine is reported to have caused severe side effects on the heart and blood vessels. Extreme caution is advised while using this medicine as these side effects can be fatal. Special attention is required if you have a pre-existing heart condition.

Kidney diseases

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. The missed dose can be skipped if it is almost time for the next scheduled dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects.
Interaction with Medicine

Amitriptyline

Clarithromycin

Fluconazole

Cimetidine

Cyclosporine

Disease interactions

Gastrointestinal perforations

This medicine is not recommended in patients suffering from gastrointestinal hemorrhage, mechanical obstruction, or perforation diseases due to the increased risk of severe adverse effects. Replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice or grapefruit is not recommended while taking this medicine due to an increased risk of irregular heartbeat. Any symptoms of irregular heartbeat should be reported to the doctor.
Lab interactions
Information not available.
Take this medicine exactly as advised by the doctor. It can be taken 15 minutes before a meal. Do not take in larger amounts than prescribed. Consult the doctor if you experience any undesirable side effects.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine acts by increasing the concentration of a certain chemical at the nerve endings causing an increase in stomach muscle movement. This helps in the faster movement of food from the stomach to the intestine.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Gastrointestinal agents

Schedule

Schedule H

Cisapride - DrugBank [Internet]. Drugbank.ca. 2020 [cited 16 March 2020]. Available from:

https://www.drugbank.ca/drugs/DB00604

Cisapride: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 16 March 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a694006.html

Cisapride [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 16 March 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Cisapride
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Information on this page was last updated on 16 Apr 2020

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