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PRECIZE 1.5 G INJECTION

Manufactured bySun Pharma Laboratories Ltd.
ContainsCefoperazone (1000 mg) + Sulbactam (500 mg)
Description

PRECIZE 1.5 G INJECTION is a combination medicine used to treat infections of the respiratory tract, urinary tract, bone and joints, intraabdominal infections, skin and soft tissue infections, etc. caused by susceptible bacteria. This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects.

Side effects

Major & minor side effects for PRECIZE 1.5 G INJECTION

  • Headache
  • Nausea and Vomiting
  • Diarrhea
  • Rash
  • Itching
  • Blood in urine
  • Decrease in blood cell count
  • Gastrointestinal side effects
  • Chills
  • Injection site Thrombophlebitis
  • Seizures
  • Injection site pain

Uses of PRECIZE 1.5 G INJECTION

What is it prescribed for?

  • Urinary tract infections
  • Respiratory Tract Infection
  • Intra-abdominal Infections
  • Bacterial Septicemia
  • Skin and Soft tissue infections
  • Gynecologic infections
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed rapidly after an intravenous or intramuscular administration.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Use of this medicine within 48-72 hours of alcohol consumption may cause a disulfiram like-reaction. This reaction is characterized by symptoms such as severe vomiting, abdominal pain, headache, palpitations, difficulty in breathing, sweating, increased heart rate, etc. Consumption of alcohol is not recommended during treatment with this medicine and for several days after the therapy has been stopped. Any unusual symptoms should be reported to the doctor on priority. It is advised that you inform your doctor if you have consumed alcohol before beginning therapy with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to cefoperazone, sulbactam, other beta-lactam antibiotics, or any other inactive ingredients present along with these medicines.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Renal impairment

This medicine should be used with caution in patients with a known history of renal impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Intravenous Use

When administered as an intravenous infusion, this medicine should be administered over a duration of 15 to 60 minutes. When administered as an intravenous injection, this medicine should be administered over a minimum of 3 minutes.

Drug resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and may even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Clostridium difficile-associated Diarrhea

Inform the doctor immediately in case of severe and persistent diarrhea. Antibiotic therapy will cause an imbalance in the normal microbial flora in the large intestine. This may decrease the gut-friendly bacteria and may promote the growth of a bacteria called Clostridium difficile, resulting in diarrhea. Appropriate corrective measures and replacement with a suitable alternative may be necessary based on the clinical condition.

Liver diseases

This medicine should be used with extreme caution in patients with a known history of liver diseases or active liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is recommended for such patients. The dose of cefoperazone should not exceed 4 g/day for such patients unless specifically required and only with close monitoring of serum cefoperazone concentrations and liver function. In patients with liver and renal function impairment, the cefoperazone dose should not exceed 2 g/day.

Electrolyte imbalance

This medicine should be used with caution in patients with a known history of electrolyte imbalance since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of electrolyte levels, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Epilepsy

This medicine should be used with caution in patients with a known history of epilepsy due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered by a qualified health care professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Use of this medicine within 48-72 hours of alcohol consumption may cause a disulfiram like-reaction. This reaction is characterized by symptoms such as severe vomiting, abdominal pain, headache, palpitations, difficulty in breathing, sweating, increased heart rate, etc. Consumption of alcohol is not recommended during treatment with this medicine and for several days after the therapy has been stopped. Any unusual symptoms should be reported to the doctor on priority. It is advised that you inform your doctor if you have consumed alcohol before beginning therapy with this medicine.
Interaction with Medicine

Aminoglycoside antibiotics

Loop diuretics

Anticoagulants

Probenecid

Disease interactions

Renal impairment

This medicine should be used with caution in patients with a known history of renal diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions

Benedict's or Fehling's Test

This medicine may give a false positive result for glucose in the urine with Benedict's or Fehling's reagent. A different reagent may be used for detecting glucose in the urine.

Coomb's test

Use of this medicine may give a false positive result for the Coombs test. This test is used to detect anemia caused by the excessive destruction of red blood cells. An alternative test may be used during treatment with this medicine.
This medicine should be administered by a qualified health care professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesirable side effects to the doctor promptly.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Cefoperazone interferes with the bacterial cell wall formation and stops the growth of bacteria. Sulbactam inhibits some chemicals produced by the bacteria and makes the bacteria more sensitive to cefoperazone activity.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Beta-lactamase inhibitors, Third generation cephalosporins

Schedule

Schedule H

[Internet]. CiplaMed. 2018 [cited 1 September 2018]. Available from:

https://ciplamed.com/content/zosul-injection

Zuventus Healthcare [Internet]. Zuventus.co.in. 2018 [cited 1 September 2018]. Available from:

http://www.zuventus.co.in/patient_wise_products_selected.aspx?Medi_Id=102

Cefoperazone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 1 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB01329

Sulbactam [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 19 March 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/sulbactam#section=Top

Sulbactam - DrugBank [Internet]. Drugbank.ca. 2018 [cited 19 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB09324
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Information on this page was last updated on 23 Oct 2018

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.