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Placidin 400 MG Tablet XR
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Placidin 400 MG Tablet XR

Manufactured byLupin Ltd.
ContainsQuetiapine
Description
Placidin 400 MG Tablet XR is an antipsychotic medicine containing Quetiapine as an active ingredient. It is used for the treatment of mental conditions like Schizophrenia (a person develops unreal thoughts and behaviour), depression (a condition that includes low mood and loss of interest), and bipolar disorder (extreme mood swings and changes in a person's energy levels and behaviour). It works by stopping the release of various chemical substances in the brain responsible for such mental conditions. Placidin 400 MG Tablet XR can cause side effects like weight gain, weakness, stomach upset, low blood pressure, etc. Consult your doctor if these side effects persist or worsen. Avoid driving vehicles or operating machines as this medicine can make you dizzy or drowsy. Placidin 400 MG Tablet XR can be taken with or without food. Take it at the same time every day to maintain a constant level of medicine in your body. The dose and duration of treatment will be decided by your doctor based on your underlying condition. Do not stop taking the medicine suddenly, as it may cause withdrawal symptoms (such as dizziness, irritability, sleep problems, nausea, vomiting, headache, etc.). Placidin 400 MG Tablet XR is not recommended if you are allergic to it. Inform your doctor about your current medications and existing medical conditions on priority. This will help your doctor adjust the dose to avoid undesired effects. Consult your doctor if you are pregnant before taking Placidin 400 MG Tablet XR. It is known to excrete into breast milk, hence your doctor will advise you to discontinue medicine or breastfeeding. It is not recommended for use in children below ten years of age as safety and efficacy have not been established.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Placidin 400 MG Tablet XR

  • Dizziness
  • Chills
  • Confusion
  • Blurred vision
  • Loss of balance control
  • Difficulty or painful urination
  • Irregular menstrual periods
  • Loss of appetite
  • Weight gain
  • Constipation
  • Headache
  • Acid or sour stomach
  • Decreased appetite
  • Sneezing

Uses of Placidin 400 MG Tablet XR

What is it prescribed for?

  • Schizophrenia
  • Bipolar disorder
  • Depression
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Placidin 400 MG Tablet XR may take four to six weeks to fully show its effect.
  • How long do the effects of this medicine last?
    The amount of time for which Placidin 400 MG Tablet XR remains effective in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Placidin 400 MG Tablet XR.
  • Can this medicine be taken during pregnancy?
    Placidin 400 MG Tablet XR is not recommended for use during pregnancy unless necessary. Hence consult your doctor before taking this medicine if you are pregnant. Your doctor may weigh the risks and benefits of using this medicine before prescribing it to you.
  • Can this medicine be taken while breast-feeding?
    It is known to excrete into breast milk, hence your doctor will advise you to discontinue Placidin 400 MG Tablet XR or breastfeeding.

Allergy

Avoid taking Placidin 400 MG Tablet XR if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population

Pregnancy

Placidin 400 MG Tablet XR is not recommended for use during pregnancy unless necessary. Hence consult your doctor before taking this medicine if you are pregnant. Your doctor may weigh the risks and benefits of using this medicine before prescribing it to you.

Breast-feeding

It is known to excrete into breast milk, hence your doctor will advise you to discontinue Placidin 400 MG Tablet XR or breastfeeding.
General warnings

Suicidal thoughts

Placidin 400 MG Tablet XR should be used with caution due to the increased risk of suicidal thoughts. Closely observe for any change in behaviour or mood while taking this medicine. Consult your doctor immediately if you experience suicidal thoughts or behaviour.

Diabetes and Dyslipidaemia

Diabetes is a condition in which there is an increase in blood sugar levels. Dyslipidaemia is having blood lipid levels (fatty substances) too high or low. Placidin 400 MG Tablet XR may increase the blood sugar levels and cholesterol levels in the body. Your doctor may recommend tests for periodic monitoring of your blood sugar, cholesterol, and fat levels.

Blood cells count

Placidin 400 MG Tablet XR may reduce the blood cell count, especially WBC (neutrophils). Report any symptoms such as fever, weakness during the treatment, etc. to your doctor. Your doctor may recommend regular monitoring of your blood cell count.

Tardive dyskinaesia

Tardive dyskinaesia is a movement disorder characterised by involuntary and abnormal movements of the jaw, lips, tongue, trunk, and extremities. Placidin 400 MG Tablet XR should be used with extreme caution as it may cause tardive dyskinaesia.

Use in children

Placidin 400 MG Tablet XR is not recommended for use in children younger than ten years of age as the safety and efficacy data are not clinically established.

Discontinuation syndrome

Abrupt discontinuation of Placidin 400 MG Tablet XR may increase the risk of side effects, especially if you have been using a high dose for a long duration. Your doctor may recommend a gradual dose reduction to minimise these reactions. Do not stop the use of this medicine without consulting your doctor.

Driving vehicles or operating machines

Placidin 400 MG Tablet XR may cause dizziness or drowsiness. Avoid driving vehicles or operating machines if you experience such symptoms during treatment with this medicine.

Neuroleptic malignant syndrome

Neuroleptic malignant syndrome is a rare life-threatening condition characterised by fever, an abnormally high body temperature, muscle rigidity, altered mental status, irregular pulse or blood pressure, etc. Placidin 400 MG Tablet XR should be used with extreme caution if you have or have had neuroleptic malignant syndrome, as it can trigger or aggravate the condition.

Priapism

Placidin 400 MG Tablet XR may cause priapism (painful or prolonged erection lasting for more than four hours) in men. In such cases, seek immediate medical attention.

Heart conditions

Placidin 400 MG Tablet XR should be used with caution as it may cause cardiovascular (heart and blood vessels) problems such as QT prolongation (a condition in which your heart muscles take a longer time to recharge between a heartbeat) or an increase in blood pressure.

Missed Dose

Do not miss the dose of Placidin 400 MG Tablet XR. In case you miss a dose, take it as soon as you remember. However, if it is time for the next dose, then skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Do not take more than the prescribed dose of Placidin 400 MG Tablet XR. Seek emergency medical treatment in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Ketoconazole

Metformin

Tramadol

Disease interactions

Dementia

Placidin 400 MG Tablet XR is not recommended for use in case of dementia-related psychosis (memory loss along with hallucinations) as it may increase the risk of heart failure or infectious diseases like pneumonia (lung infection). This risk is especially high in the elderly. Your doctor may recommend replacement with a suitable alternative based on your clinical condition.

Seizures

A seizure is a condition in which there is uncontrolled body movements due to an electrical disturbance in the brain. Placidin 400 MG Tablet XR should be used with caution if you have a history of seizures or conditions that lower the seizure threshold (likelihood of having a seizure). Your doctor may recommend an appropriate dose adjustment or replacement with a suitable alternative based on your clinical condition.

Liver Disease

Placidin 400 MG Tablet XR is broken down in the liver and should be used with caution if you have liver problems. Impaired liver function may cause an accumulation of this medicine in the body, thus increasing the risk of side effects. Your doctor may adjust the dose based on your clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Placidin 400 MG Tablet XR with or without food, as instructed by your doctor. Do not break, chew, or crush the tablet. Swallow as a whole with a glass of water. Follow all the directions mentioned on the prescription label/package insert. Do not take in larger or smaller amounts than prescribed. Consult your doctor if you experience any undesirable effects that persist or worsen. It is used for long-term treatment. Hence avoid discontinuing this medicine without consulting your doctor as your condition may become worse. Also, you may experience withdrawal symptoms such as trouble sleeping, irritability, diarrhoea, headache, etc. Your doctor may recommend periodic blood tests to monitor your blood sugar and cholesterol levels during treatment with this medicine. Placidin 400 MG Tablet XR may cause drowsiness or dizziness. Hence, avoid driving vehicles or operating machines if you experience such symptoms after taking this medicine. Drink plenty of water and avoid getting dehydrated while you are taking this medicine. Also, avoid doing strenuous exercise or getting exposed to extreme heat. This medicine may impair the body's ability to regulate body temperature. Consult your doctor immediately if you experience mood changes or thoughts of self-harm.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Placidin 400 MG Tablet XR works by inhibiting the release of certain chemical substances in the brain which are responsible for causing the symptoms associated with schizophrenia and bipolar disorder.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Atypical antipsychotics

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2022. These highlights do not include all the information needed to use QUETIAPINE TABLETS safely and effectively. See full prescribing information for QUETIAPINE TABLETS. QUETIAPINE tablets, for oral use Initial U.S. Approval: 1997. [online] Available at: [Accessed 28 January 2022].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=904f80af-44b6-d964-1680-ac9e6b61327b

Drugs, H., 2022. Quetiapine: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: [Accessed 28 January 2022].

https://medlineplus.gov/druginfo/meds/a698019.html

2022. [online] Available at: [Accessed 22 July 2022].

https://www.medicines.org.uk/emc/medicine/2295#gref

Ebs.tga.gov.au. 2022. TGA eBS - Product and Consumer Medicine Information Licence. [online] Available at: [Accessed 28 January 2022].

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2020-PI-02417-1&d=20220128172310101

Quetiapine: Atypical antipsychotic use & side effects (no date) YoungMinds. Available at: (Accessed: April 19, 2023).

https://www.youngminds.org.uk/young-person/medications/quetiapine/#:~:text=How%20long%20does%20quetiapine%20take,over%20the%20first%20few%20weeks.
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Information on this page was last updated on 19 Apr 2023

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