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Phenykem 50 MG Injection

Manufactured byAlkem Laboratories Ltd.
ContainsPhenytoin
Description

Phenykem 50 MG Injection is an anticonvulsant used to treat severe epileptic seizures or fits (status epilepticus). It is also used to control and/or prevent seizures that may occur during or after brain surgeries or severe head injuries.

Side effects

Major & minor side effects for Phenykem 50 MG Injection

  • Decreased coordination
  • Nervousness
  • Unsteadiness
  • Shaking of hands or feet
  • Unusual facial expressions
  • Trouble sleeping
  • Uncontrolled eye movements
  • Yellow colored eyes or skin
  • Skin rash
  • Headache
  • Pain at the injection site

Uses of Phenykem 50 MG Injection

What is it prescribed for?

  • Seizures
  • Status Epilepticus
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed in 0.5-1 hour after administration.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to phenytoin or any other inactive ingredients present along with the formulation.

Delavirdine

This medicine is not recommended for use in patients receiving delavirdine, an antiviral medicine used for the treatment of an HIV infection, since it may worsen the patient's condition.

Heart rhythm disorders

This medicine is not recommended for use in patients suffering from heart rhythm disorders such as sinus bradycardia, sino-atrial block, second or third-degree AV-block, Adams-Stokes syndrome, etc. due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Blood cell count

This medicine may cause neutropenia, anemia, and aplastic anemia. Frequent monitoring of blood cell count is necessary. Any signs of low blood count should be reported to the doctor. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Suicidal thoughts

This medicine may increase the risk of suicidal thoughts upon treatment. Therefore, it should be used with caution, especially in patients suffering from depression or suicidal tendencies. Close monitoring of mood and behavior is necessary for such patients. Appropriate caregiver and patient counseling, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Skin reactions

This medicine should be used with caution since it may cause skin reactions like Stevens-Johnson syndrome, toxic epidermal necrolysis, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), etc. in some patients. The treatment should be discontinued if any symptoms of a skin rash appear.

Effects on bone

This medicine is known to decrease bone density and may increase the risk of osteoporosis and osteomalacia. Inform the doctor if you have any bone disorder. Close monitoring of Vitamin-D levels and radiological findings is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Megaloblastic anemia

This medicine should be used with caution in patients suffering from megaloblastic anemia or folate deficiency due to the increased risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Voriconazole

Warfarin

Ethinyl Estradiol

Metaxalone

Disease interactions

Porphyria

This medicine should be used with caution patients with porphyria due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Arrhythmias

This medicine should be used with caution in patients suffering from cardiovascular diseases and conduction abnormalities due to the increased risk of worsening of the patient's condition. Close monitoring of the heart function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients suffering from diabetes mellitus due to the increased risk of elevated blood sugar levels. Close monitoring of blood sugar levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients suffering from liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients suffering from kidney impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by decreasing the abnormal electrical activity in the brain by inhibiting the repetitive firing of neurons.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Hydantoin anticonvulsants

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2020 [cited 12 May 2020]. Available from:

https://www.medicines.org.uk/emc/files/pil.4326.pdf

Phenytoin Sodium 100 mg Injection, USP 2 mL Phenytoin Sodium Injection for intravenous or intramuscular use. Initial U.S. Approval: 1953 [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 12 May 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=31d00e75-4fe0-4aec-9cba-c86cb78762c5&type=display

Phenytoin Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 12 May 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a619062.html

[Internet]. Medsafe.govt.nz. 2020 [cited 12 May 2020]. Available from:

https://www.medsafe.govt.nz/profs/Datasheet/d/dblphenytoininj.pdf

[Internet]. Accessdata.fda.gov. 2020 [cited 12 May 2020]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/010151s036lbl.pdf
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Information on this page was last updated on 19 May 2020

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