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Olkem Trio 12.5 Tablet

Manufactured byALKEM LABORATORIES LTD
ContainsChlorthalidone (12.5 mg) + Cilnidipine (10 mg) + Olmesartan (20 mg)
Description

Olkem Trio 12.5 Tablet is a combination medicine which may be used for the treatment of high blood pressure (hypertension). It may also help to reduce the risk of adverse effects on the heart (complications) associated with high blood pressure levels. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

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Side effects

Major & minor side effects for Olkem Trio 12.5 Tablet

  • Headache
  • Unusual tiredness and weakness
  • Dry mouth
  • Chills
  • Muscle pain
  • Skin Rash
  • Stomach pain
  • Low blood pressure (hypotension)
  • Constipation
  • Nausea and Vomiting
  • Dizziness
  • Blurred vision

Uses of Olkem Trio 12.5 Tablet

What is it prescribed for?

  • Hypertension
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time taken for this medicine to show its effect is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains effective in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of dizziness, fainting, and very low blood pressure levels. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to chlorthalidone, other sulfonamides, cilnidipine, olmesartan, any other angiotensin-receptor blockers, or any other inactive ingredients present along with these medicines.

Aliskiren

Coadministration of aliskiren and Olkem Trio 12.5 Tablet is not recommended due to the increased risk of serious adverse effects. Coadministration of these medicines is contraindicated in patients suffering from diabetes, patients with CrCl less than 60 ml/min and in elderly patients since the risk of serious adverse effects is significantly high in these patients.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine, due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (CrCl < 30 ml/min) due to the increased risk of serious adverse effects.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of severe adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Hyperkalemia

This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Hypotension

Use of this medicine may increase the risk of hypotension (low blood pressure levels), especially in patients with volume depletion. Regular monitoring of blood pressure levels is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patient's suffering from liver diseases due to an increase in the risk of serious adverse effects. Close monitoring of liver function is advised while taking this medicine. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Volume and electrolyte disturbances

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function tests is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of dizziness, fainting, and very low blood pressure levels. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.
Interaction with Medicine

Aliskiren

Captopril

Insulin

Ziprasidone

Carbamazepine

Amiodarone

Cisapride

Cimetidine

Primaquine

Lithium

Disease interactions

Congestive heart failure

This medicine should be used with extreme caution in patients with congestive heart failure due to the increased risk of kidney function impairment and worsening of the patient's condition. Close monitoring of heart function, blood pressure, and kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes Mellitus

Use of this medicine may alter blood glucose levels in patients with diabetes mellitus. Close monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments either for this medicine or the antidiabetic medicine or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia (increased uric acid levels in the blood) since it may decrease the uric acid excretion and further worsen the patient's condition. Close monitoring of uric acid levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may increase the cholesterol and triglyceride levels. Close monitoring of cholesterol and triglyceride levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as dizziness, headache, swelling of hands and feet, etc.
Lab interactions

Urinary vanillylmandelic acid

Report the use of this medicine if you have been asked to undergo this test for the presence of adrenal gland tumor. Use of this medicine is likely to give a false value that might be higher than normal.
Take this medicine exactly as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Chlorthalidone works by increasing the excretion of water and sodium from the kidneys. This helps in bringing down the blood pressure as well as swelling (edema). Cilnidipine and Olmesartan both relax the blood vessels, thus improving blood flow and reducing blood pressure levels. Their combination is thus effective in the treatment of high blood pressure.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Thiazide diuretics, Calcium channel blocking agents, Angiotensin receptor blockers, Antihypertensive combinations

Schedule

Schedule H

Olmesartan: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 17 August 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a603006.html

Cilnidipine | C27H28N2O7 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 17 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/cilnidipine#section=Top

Chlorthalidone - DrugBank [Internet]. Drugbank.ca. 2018 [cited 17 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00310
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Information on this page was last updated on 22 Mar 2019

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