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Maczone Plus 1.5 Injection
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Maczone Plus 1.5 Injection

Manufactured byMACLEODS PHARMACEUTICALS PVT.LTD
ContainsCeftriaxone (1000 mg) + Sulbactam (500 mg)
Description
Maczone Plus 1.5 Injection is a combination of Ceftriaxone and Sulbactam. It is an antibiotic used to treat bacterial infections affecting the lungs, nose, throat, ears, heart, skin, urinary tract, etc. This medicine works by attacking the cell walls of the bacteria and eventually kills them. Maczone Plus 1.5 Injection is not effective against infections caused by viruses. Maczone Plus 1.5 Injection shows side effects like diarrhoea, pain at the injection site, headache, weakness, and dizziness. Do not use this medicine if you are allergic to it. Contact your doctor if any side effects are seen for a long time. Maczone Plus 1.5 Injection is administered into your vein or muscle by a health care professional in a hospital or clinical setting. Do not inject it on your own. Your doctor will determine the dose you need each day and how often the injections should be given. Once an antibiotic is started, it is always recommended to finish the entire course of treatment. Do not use Maczone Plus 1.5 Injection unless prescribed by your doctor. Unnecessary use of an antibiotic can reduce its effectiveness. Maczone Plus 1.5 Injection may interact with calcium-containing products. Hence, avoid using this medicine in infants and neonates receiving calcium products. Maczone Plus 1.5 Injection is not recommended for use in infants and neonates (newborn child below 28 days of age). This medicine maybe safe for use in pregnancy. However, it is always best to consult your doctor if you are pregnant, or are breastfeeding. Inform your doctor if you have any liver, kidney, or stomach and intestinal problems before taking the medicine.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Maczone Plus 1.5 Injection

  • Diarrhoea
  • Nausea and Vomiting
  • Itching
  • Fatigue
  • Chills
  • Black or tarry stools
  • Fever
  • Difficult or painful urination
  • Sore throat
  • Abdominal pain
  • Dizziness
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Acid or sour stomach
  • Change in taste
  • Excessive air or gas in stomach
  • Pain at the injection site
  • Headache

Uses of Maczone Plus 1.5 Injection

What is it prescribed for?

  • Urinary tract infections
  • Bacterial Meningitis
  • Skin and Skin Structure Infection
  • Acute bacterial otitis media
  • Lower Respiratory Tract Infection
  • Surgical prophylaxis
  • Intra-abdominal Infection
  • Pelvic inflammatory disease
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Maczone Plus 1.5 Injection starts immediately after the intravenous or intramuscular administration.
  • How long do the effects of this medicine last?
    It is no know how long the effect of Maczone Plus 1.5 Injection lasts in the body.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Maczone Plus 1.5 Injection.
  • Can this medicine be taken during pregnancy?
    Maczone Plus 1.5 Injection may be safe for use in pregnancy to treat bacterial infections. Animal studies indicate no risk to the foetus. However, data on human studies are not available. Therefore, use Maczone Plus 1.5 Injection only upon your doctor's recommendation.
  • Can this medicine be taken while breast-feeding?
    Maczone Plus 1.5 Injection should be used in breastfeeding women only if absolutely necessary. Hold feeding until you complete the treatment course. Observe your baby for any side effects like diarrhoea and rashes.

Allergy

Avoid using Maczone Plus 1.5 Injection if you are allergic to it. Inform your doctor if there is any history of allergy to Maczone Plus 1.5 Injection. If you notice any symptoms such as skin rashes, itching/swelling anywhere on your body, dizziness, breathing difficulty, etc., inform your doctor and seek immediate medical attention.

Calcium-containing products

Do not administer Maczone Plus 1.5 Injection in neonates (babies ≤ 28 days) who are receiving calcium-containing intravenous solutions or infusions such as parenteral nutrition. This medicine may accumulate along with calcium in the lungs and kidneys.
Warnings for special population

Pregnancy

Maczone Plus 1.5 Injection may be safe for use in pregnancy to treat bacterial infections. Animal studies indicate no risk to the foetus. However, data on human studies are not available. Therefore, use Maczone Plus 1.5 Injection only upon your doctor's recommendation.

Breast-feeding

Maczone Plus 1.5 Injection should be used in breastfeeding women only if absolutely necessary. Hold feeding until you complete the treatment course. Observe your baby for any side effects like diarrhoea and rashes.
General warnings

Prothrombin time

There may be alterations in prothrombin time (a test used to check for bleeding problems) while receiving Maczone Plus 1.5 Injection. Regular monitoring of prothrombin time and Vitamin K administration may be necessary, especially if you have low vitamin K levels, if you are malnourished, or have liver problems.

Antibiotic resistance

Antibiotic resistance occurs when bacteria develop the ability to defeat the medicine that was intended to kill them. Hence, to avoid such resistance you should always complete the entire course of treatment with Maczone Plus 1.5 Injection even if you feel better after a few doses.

Diarrhoea

Maczone Plus 1.5 Injection can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Inform your doctor if you experience severe diarrhoea while receiving this medicine.

Use in neonates

Maczone Plus 1.5 Injection is not recommended for use in neonates (babies less than 28 days of age) since the safety and efficacy of use are not clinically established.

Liver disease

Regular monitoring of the liver enzyme levels is necessary while administering Maczone Plus 1.5 Injection and even after treatment with this medicine is complete.

Driving or operating machines

Maczone Plus 1.5 Injection may cause dizziness. Hence, do not perform activities such as driving vehicles or operating machines.

Missed Dose

Since Maczone Plus 1.5 Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since Maczone Plus 1.5 Injection is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Probenecid

Ethinyl Estradiol

Cyclosporine

Cholera Vaccine (live)

Disease interactions

Renal impairment

Maczone Plus 1.5 Injection is filtered by the kidney and moved out of the body through urine. If you have any medical conditions that affect the kidneys, then this medicine can cause further damage.

Gastrointestinal Diseases

Maczone Plus 1.5 Injection can kill the helpful bacteria in your stomach or intestine and leads to diarrhoea. Therefore use this medicine with extreme caution if you have any stomach or intestinal problems, particularly colitis (inflammation of the large intestine), as it may worsen your health condition.

Seizure disorders

Seizure disorder (fits) is a condition due to uncontrolled electrical activity between brain cells that causes temporary abnormalities in muscle tone and movements, behaviour, etc. Avoid using Maczone Plus 1.5 Injection or maintain caution if you have a history of seizure episodes, as it can trigger a fresh attack. Your doctor will adjust your dose or recommend a suitable alternative as required.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Maczone Plus 1.5 Injection is for parenteral use. You should not administer Maczone Plus 1.5 Injection on your own. It should be administered by a qualified healthcare professional in a clinical or hospital setting. Your doctor will determine an appropriate dosage based on your clinical condition. Report any undesirable side effects to your doctor promptly. Inform your doctor about all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Maczone Plus 1.5 Injection is a combination of Ceftriaxone and Sulbactam. Ceftriaxone works by preventing the formation of bacterial cell walls. This helps in stopping the growth and multiplication of the bacteria and eventually kills them. Sulbactam inhibits some chemicals produced by the bacteria and makes them more sensitive to ceftriaxone activity.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Third generation cephalosporins, Beta-lactamase inhibitors

Schedule

Schedule H

Piccolopharma.com. 2021. Piccolo Pharma | Piccocef-S 1.5g. [online] Available at: < [Accessed 1 June 2021].

http://www.piccolopharma.com/products/piccocef-s-1-5g/>

Pubchem.ncbi.nlm.nih.gov. 2021. Ceftriaxone. [online] Available at: < [Accessed 1 June 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Ceftriaxone>

Pubchem.ncbi.nlm.nih.gov. 2021. Sulbactam. [online] Available at: < [Accessed 1 June 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Sulbactam>
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Information on this page was last updated on 14 Sep 2021

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