Grandem Injection

Manufactured byARISTO PHARMA
ContainsGranisetron
Description

Grandem Injection is an antiemetic drug used to prevent nausea and vomiting caused by chemotherapy, radiation therapy as well as nausea and vomiting associated with surgeries. This medicine is not recommended for use in patients less than 2 years of age.

Substitutes

List of substitutes for Grandem Injection

Side effects

Major & minor side effects for Grandem Injection

  • Headache
  • Constipation
  • Diarrhea
  • Rashes
  • Dizziness
  • Sleepiness
  • Irregular heartbeat

Uses of Grandem Injection

What is it prescribed for?

  • Chemotherapy or Radiation therapy induced nausea and vomiting
  • Post operative nausea and vomiting
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 to 4 minutes of intravenous administration and within 30 to 60 minutes of oral administration.
  • Duration of effect
    The effect of this medicine lasts for a maximum duration of 24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to granisetron or any other inactive ingredients present along with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.
General warnings

Serotonin Syndrome

This medicine should be used with caution due to the increased risk of serotonin syndrome. This risk is especially higher in patients receiving serotogenic drugs. Report any symptoms such as dizziness, increased heart rate, changes in blood pressure, flushing, vomiting, nausea, diarrhea, etc. to the doctor immediately. Appropriate corrective measures or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Since this medicine is usually administered/taken in the clinical/hospital setting, the likelihood of missing a dose is very low.

Overdose

Since this medicine is usually administered/taken in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Apomorphine

Fentanyl

Selective Serotonin Reuptake inhibitors

Disease interactions

Arrhythmias

This medicine should be used with caution in patients with pre-existing arrhythmias or cardiac conduction disorders due to the increased risk of worsening of the patient's condition. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Carefully follow all the instructions given by your doctor and take/receive this medicine exactly as directed. Report any unusual symptoms or worsening of condition to the doctor immediately. It is advised that you report to the doctor all your current medicines including any herbs and supplements as well as your medical history before beginning treatment with this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine blocks the action of certain chemicals in the body that are responsible for causing nausea and vomiting.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antiemetics, 5HT3 receptor antagonists

Schedule

Schedule H

[Internet]. CiplaMed. 2018 [cited 24 July 2018]. Available from:

https://ciplamed.com/content/granicip-injection

[Internet]. Medicines.org.uk. 2018 [cited 24 July 2018]. Available from:

https://www.medicines.org.uk/emc/product/6423/smpc#POSOLOGY

[Internet]. Accessdata.fda.gov. 2018 [cited 24 July 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020239s021,020305s014,021238s007lbl.pdf
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