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Grandem Injection

Manufactured byARISTO PHARMA
ContainsGranisetron
Description
Grandem Injection is an antiemetic drug used to prevent nausea and vomiting caused by chemotherapy, radiation therapy as well as nausea and vomiting associated with surgeries. This medicine is not recommended for use in patients less than 2 years of age.

Side effects

Major & minor side effects for Grandem Injection

  • Headache
  • Constipation
  • Diarrhea
  • Rashes
  • Dizziness
  • Sleepiness
  • Irregular heartbeat
  • Pain at the injection site
  • Blurred vision
  • Fever

Uses of Grandem Injection

What is it prescribed for?

  • Chemotherapy or Radiation therapy induced nausea and vomiting
  • Post operative nausea and vomiting
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 to 4 minutes of administration.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for a maximum duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to granisetron or any other inactive ingredients present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or may prescribe an alternative medicine based on your clinical condition.
General warnings

Serotonin Syndrome

This medicine should be used with caution due to the increased risk of serotonin syndrome. This risk is especially higher in patients receiving serotogenic drugs. Report any symptoms such as dizziness, increased heart rate, changes in blood pressure, flushing, vomiting, nausea, diarrhea, etc. to the doctor immediately. Appropriate corrective measures or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Liver disease

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

QT Prolongation

This medicine should be used with extreme caution in patients with prolonged QT due to the increased risk of worsening of the patient's condition. Regular monitoring of electrolyte levels and kidney function tests are necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Tramadol

Apomorphine

Formoterol

Fentanyl

Azithromycin

Selective Serotonin Reuptake inhibitors

Hydroxychloroquine

Promazine

Disease interactions

Arrhythmias

This medicine should be used with caution in patients with pre-existing arrhythmias or cardiac conduction disorders due to the increased risk of worsening of the patient's condition. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver Disease

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine blocks the action of certain chemicals in the body that are responsible for causing nausea and vomiting.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antiemetics, 5HT3 receptor antagonists

Schedule

Schedule H

[Internet]. CiplaMed. 2018 [cited 24 July 2018]. Available from:

https://ciplamed.com/content/granicip-injection

[Internet]. Medicines.org.uk. 2018 [cited 24 July 2018]. Available from:

https://www.medicines.org.uk/emc/product/6423/smpc#POSOLOGY

[Internet]. Accessdata.fda.gov. 2018 [cited 24 July 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020239s021,020305s014,021238s007lbl.pdf

Granisetron Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 19 June 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a694011.html
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Information on this page was last updated on 29 Jun 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.