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Defrijet 250 Tablet
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Defrijet 250 Tablet

Manufactured bySUN PHARMA LABORATORIES LTD
ContainsDeferasirox
Description
Defrijet 250 Tablet is a medicine used to treat an excessive accumulation of iron in your body due to multiple blood transfusions, in adults and children above two years of age. It is also used for removing an excess of iron in the body that may be caused by a genetic disorder known as non-transfusion-dependent thalassemia (a condition characterised by severe anaemia that requires occasional or frequent blood transfusions for a certain time), in adults and children above 10 years of age. Defrijet 250 Tablet works by attaching to the iron in your body so that it can be removed from your body in the stool. Defrijet 250 Tablet may cause some side effects like stomach pain, nausea, vomiting, diarrhoea, etc. Inform your doctor if these side effects persist or become severe. Defrijet 250 Tablet should be taken on an empty stomach, at least 30 minutes before a meal. Make sure to take this medicine at a fixed time daily to avoid missing a dose. Do not take more or less than the recommended dose. Defrijet 250 Tablet should be avoided if you are allergic to it. It is not recommended for use if you have severe liver or kidney problems, advanced cancer, or low platelet (blood clot-forming cells) count. Inform your doctor if you have other medical conditions or taking any other medications. Consult your doctor before taking this medicine if you are pregnant or are breastfeeding.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Defrijet 250 Tablet

  • Nausea and vomiting
  • Dizziness
  • Earache
  • Stomach pain
  • Loss of vision or blurred vision
  • Hearing impairment
  • Black or tarry stools
  • Fever
  • Cough or hoarseness
  • Abnormal blood counts
  • Diarrhoea

Uses of Defrijet 250 Tablet

What is it prescribed for?

  • Iron overload
  • Non-transfusion dependent thalassemia (NTDT)
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time taken by Defrijet 250 Tablet to show its effects is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which Defrijet 250 Tablet remains effective in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Defrijet 250 Tablet.
  • Can this medicine be taken during pregnancy?
    Animal studies indicate that Defrijet 250 Tablet may affect your developing foetus during pregnancy. However, due to limited human data, consult your doctor before taking this medicine if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Defrijet 250 Tablet may pass into the breastmilk. Hence, consult your doctor before taking this medicine if you are breastfeeding.

Allergy

Avoid taking Defrijet 250 Tablet if you are allergic to it. Inform your doctor if you notice any symptoms such as a skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness or breathing difficulty, etc.

Myelodysplastic syndrome

Myelodysplastic syndromes are a group of cancers characterised by the inability of the bone marrow to produce healthy blood cells. Defrijet 250 Tablet is not recommended in such cases as it may worsen the condition.

Advanced malignancies

Advanced malignancies are end-stage cancer that can not be cured or controlled with treatment. Defrijet 250 Tablet is not recommended for use in case of advanced cancers.

Severe kidney disease

Defrijet 250 Tablet is not recommended for use if have severe kidney problems as it may worsen your condition.

Severe liver impairment

Defrijet 250 Tablet is not recommended for use if you have severe liver problems as it may worsen your condition.
Warnings for special population

Pregnancy

Animal studies indicate that Defrijet 250 Tablet may affect your developing foetus during pregnancy. However, due to limited human data, consult your doctor before taking this medicine if you are pregnant.

Breast-feeding

Defrijet 250 Tablet may pass into the breastmilk. Hence, consult your doctor before taking this medicine if you are breastfeeding.
General warnings

Other medicines

Defrijet 250 Tablet may interact with certain medicines and cause side effects. Hence, it is advised that you inform the doctor about all your current medicines, including any herbs and supplements, before beginning treatment with this medicine.

Use in children

Use of Defrijet 250 Tablet in children is condition-specific. For treating iron overload due to multiple blood transfusions, it should not be used in children less than two years of age. For treating non-transfusion-dependent thalassemia, it should not be used in children less than 10 years of age.

Clinical monitoring

Your doctor may conduct regular tests to obtain the serum ferritin (a blood protein that contains iron) and liver iron concentration values during treatment with Defrijet 250 Tablet. These parameters play a crucial role in determining the dose regimen and treatment duration. You may also be asked to undergo other blood tests during the course of treatment with this medicine.

Use in elderly

Defrijet 250 Tablet should be used with caution in the elderly due to the increased risk of side effects.

Driving vehicles and operating machines

If you feel dizzy after taking Defrijet 250 Tablet, avoid driving vehicles or operating heavy machines until you feel normal again.

Eye conditions

Defrijet 250 Tablet should be used with caution as it may cause cataracts (the clouding of the natural lens of the eyes), increased fluid pressure inside the eyes, or other eye disorders.

Ear conditions

Defrijet 250 Tablet should be used with caution as it may cause decreased hearing and high-frequency hearing loss (problems with hearing high-pitched sounds).

Missed Dose

Take the missed dose of Defrijet 250 Tablet as soon as you remember. If it is time for the next scheduled dose, then skip the missed dose. Do not use extra medicine to make up for the missed dose.

Overdose

Never take more than the recommended dose. Contact your doctor in case of an overdose of Defrijet 250 Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Dexamethasone

Celecoxib

Amlodipine

Cisplatin

Gentamicin

Disease interactions

Gastrointestinal Disorders

Defrijet 250 Tablet should be used with extreme caution as it may cause stomach and intestinal ulcers (sores), bleeding, or perforations (holes). It risk is especially higher in the elderly who had advanced blood cancers and/or low platelet counts.
Food interactions
Avoid or limit the use of caffeine-containing products during treatment with Defrijet 250 Tablet. This medicine may increase the blood levels and effects of Caffeine, which may further increase the risk of side effects.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Defrijet 250 Tablet exactly as prescribed by your doctor. Do not take in larger or smaller quantities than recommended. Do not stop the use of this medicine without consulting your doctor. You may be asked to undergo certain tests before and during the course of treatment with this medicine. Consult your doctor if you experience any undesired effects that persist or worsen.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Defrijet 250 Tablet combines with the iron in your body and the complex thus formed is excreted in the stool.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Chelating agents

Schedule

Schedule H

Novartis.us. 2021. [online] Available at: [Accessed 17 November 2021].

https://www.novartis.us/sites/www.novartis.us/files/jadenu.pdf

Medicines.org.uk. 2021. [online] Available at: [Accessed 17 November 2021].

https://www.medicines.org.uk/emc/files/pil.4329.pdf

Drugs, H., 2021. Deferasirox: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: [Accessed 17 November 2021].

https://medlineplus.gov/druginfo/meds/a606002.html
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Information on this page was last updated on 6 Mar 2023

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