Deferasirox

Description

Deferasirox is a medicine used to treat an excessive accumulation of iron in your body due to multiple blood transfusions, in adults and children above two years of age. It is also used for removing an excess of iron in the body that may be caused by a genetic disorder known as non-transfusion-dependent thalassemia (a condition characterised by severe anaemia that requires occasional or frequent blood transfusions for a certain time), in adults and children above 10 years of age. Deferasirox works by attaching to the iron in your body so that it can be removed from your body in the stool. Deferasirox may cause some side effects like stomach pain, nausea, vomiting, diarrhoea, etc. Inform your doctor if these side effects persist or become severe. Deferasirox should be taken on an empty stomach, at least 30 minutes before a meal. Make sure to take this medicine at a fixed time daily to avoid missing a dose. Do not take more or less than the recommended dose. Deferasirox should be avoided if you are allergic to it. It is not recommended for use if you have severe liver or kidney problems, advanced cancer, or low platelet (blood clot-forming cells) count. Inform your doctor if you have other medical conditions or taking any other medications. Consult your doctor before taking this medicine if you are pregnant or are breastfeeding.

Side effects

Major & minor side effects for Deferasirox

  • Nausea and vomiting
  • Dizziness
  • Earache
  • Stomach pain
  • Loss of vision or blurred vision
  • Hearing impairment
  • Black or tarry stools
  • Fever
  • Cough or hoarseness
  • Abnormal blood counts
  • Diarrhoea

Uses of Deferasirox

What is it prescribed for?

  • Iron overload
  • Non-transfusion dependent thalassemia (NTDT)
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by Deferasirox to show its effects is not clinically established.
  • Duration of effect
    The amount of time for which Deferasirox remains effective in your body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported for Deferasirox.
  • Usage in pregnancy?
    Animal studies indicate that Deferasirox may affect your developing foetus during pregnancy. However, due to limited human data, consult your doctor before taking this medicine if you are pregnant.
  • Usage while breast-feeding?
    Deferasirox may pass into the breastmilk. Hence, consult your doctor before taking this medicine if you are breastfeeding.

Allergy

Avoid taking Deferasirox if you are allergic to it. Inform your doctor if you notice any symptoms such as a skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness or breathing difficulty, etc.

Myelodysplastic syndrome

Myelodysplastic syndromes are a group of cancers characterised by the inability of the bone marrow to produce healthy blood cells. Deferasirox is not recommended in such cases as it may worsen the condition.

Advanced malignancies

Advanced malignancies are end-stage cancer that can not be cured or controlled with treatment. Deferasirox is not recommended for use in case of advanced cancers.

Severe kidney disease

Deferasirox is not recommended for use if have severe kidney problems as it may worsen your condition.

Severe liver impairment

Deferasirox is not recommended for use if you have severe liver problems as it may worsen your condition.
Warnings for special population

Pregnancy

Animal studies indicate that Deferasirox may affect your developing foetus during pregnancy. However, due to limited human data, consult your doctor before taking this medicine if you are pregnant.

Breast-feeding

Deferasirox may pass into the breastmilk. Hence, consult your doctor before taking this medicine if you are breastfeeding.
General warnings

Other medicines

Deferasirox may interact with certain medicines and cause side effects. Hence, it is advised that you inform the doctor about all your current medicines, including any herbs and supplements, before beginning treatment with this medicine.

Use in children

Use of Deferasirox in children is condition-specific. For treating iron overload due to multiple blood transfusions, it should not be used in children less than two years of age. For treating non-transfusion-dependent thalassemia, it should not be used in children less than 10 years of age.

Clinical monitoring

Your doctor may conduct regular tests to obtain the serum ferritin (a blood protein that contains iron) and liver iron concentration values during treatment with Deferasirox. These parameters play a crucial role in determining the dose regimen and treatment duration. You may also be asked to undergo other blood tests during the course of treatment with this medicine.

Use in elderly

Deferasirox should be used with caution in the elderly due to the increased risk of side effects.

Driving vehicles and operating machines

If you feel dizzy after taking Deferasirox, avoid driving vehicles or operating heavy machines until you feel normal again.

Eye conditions

Deferasirox should be used with caution as it may cause cataracts (the clouding of the natural lens of the eyes), increased fluid pressure inside the eyes, or other eye disorders.

Ear conditions

Deferasirox should be used with caution as it may cause decreased hearing and high-frequency hearing loss (problems with hearing high-pitched sounds).

Missed Dose

Take the missed dose of Deferasirox as soon as you remember. If it is time for the next scheduled dose, then skip the missed dose. Do not use extra medicine to make up for the missed dose.

Overdose

Never take more than the recommended dose. Contact your doctor in case of an overdose of Deferasirox.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Dexamethasone

Celecoxib

Amlodipine

Cisplatin

Gentamicin

Disease interactions

Gastrointestinal Disorders

Deferasirox should be used with extreme caution as it may cause stomach and intestinal ulcers (sores), bleeding, or perforations (holes). It risk is especially higher in the elderly who had advanced blood cancers and/or low platelet counts.
Food interactions
Avoid or limit the use of caffeine-containing products during treatment with Deferasirox. This medicine may increase the blood levels and effects of Caffeine, which may further increase the risk of side effects.
Lab interactions
Information not available.
Take Deferasirox exactly as prescribed by your doctor. Do not take in larger or smaller quantities than recommended. Do not stop the use of this medicine without consulting your doctor. You may be asked to undergo certain tests before and during the course of treatment with this medicine. Consult your doctor if you experience any undesired effects that persist or worsen.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Deferasirox combines with the iron in your body and the complex thus formed is excreted in the stool.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Chelating agents

Schedule

Schedule H

Novartis.us. 2021. [online] Available at: [Accessed 17 November 2021].

https://www.novartis.us/sites/www.novartis.us/files/jadenu.pdf

Medicines.org.uk. 2021. [online] Available at: [Accessed 17 November 2021].

https://www.medicines.org.uk/emc/files/pil.4329.pdf

Drugs, H., 2021. Deferasirox: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: [Accessed 17 November 2021].

https://medlineplus.gov/druginfo/meds/a606002.html

How will this medicine affect me?

Consult top doctors online and get an answer now
Consult now
Consult now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 19 Sep 2022

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.