Deferasirox

Description

Deferasirox is used to treat an excessive accumulation of iron in the body due to multiple blood transfusions; it is used in adults and children above 2 years of age. It is also used for removing an excess of iron in the body that may be caused by a genetic disorder known as non-transfusion-dependent thalassemia (NTDT); it is used in adults and children above 10 years of age.

Side effects

Major & minor side effects for Deferasirox

  • Nausea and vomiting
  • Dizziness
  • Earache
  • Stomach pain
  • Loss of vision or blurred vision
  • Hearing impairment
  • Black or tarry stools
  • Bleeding gums
  • Unusual tiredness or weakness
  • Puffing or swelling of eyelids
  • Unusual bleeding or bruising
  • Fever
  • Cough or hoarseness
  • Respiratory tract infection
  • Abnormal blood counts

Uses of Deferasirox

What is it prescribed for?

  • Iron overload
  • Non-transfusion dependent thalassemia (NTDT)
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by this medicine to show its effects is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to deferasirox or any other inactive ingredients present in the formulation.

Poor performance status

This medicine is not recommended for use in patients with poor performance status, which is an indicator of the ability to perform certain activities of daily living without the help of others. These activities include getting dressed, eating, working a regular job, etc.

Myelodysplastic syndrome

This medicine is not recommended for use in patients with high-risk myelodysplastic syndromes, a group of disorders characterized by the inability of the bone marrow to produce healthy blood cells.

Advanced malignancies

This medicine is not recommended for use in patients suffering from advanced or end-stage cancers.

Low platelet count

This medicine is not recommended for use in patients with very low blood platelet counts (less than 50,000/mm3) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function (creatinine clearance less than 40 ml/min) due to the increased risk of serious adverse effects.

Severe liver impairment

This medicine is not recommended for use in patients with a severe impairment of liver function (Child-Pugh Category C) due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you report all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.

Pediatric use

Use of this medicine in children is condition specific. For treating iron overload, it should not be used in children less than 2 years of age. For treating thalassemia, it should not be used in children less than 10 years of age.

Clinical monitoring

Your doctor may conduct regular tests to obtain the serum ferritin and liver iron concentration values during treatment with this medicine. These parameters play a crucial role in determining the dose regimen and therapy duration. You may also be asked to undergo other blood tests during the course of treatment with this medicine.

Form based dosing

The dose regimen of this medicine is likely to vary based on the form. You are advised to not change from conventional tablets to tablets for suspension or dispersible tablets and vice versa without consulting the doctor.

Liver diseases

This medicine should be used with caution in patients with an impaired liver function due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition. It should not be used in patients suffering from a severe liver function impairment.

Kidney diseases

This medicine should be used with caution in patients with an impaired kidney function due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition. It should not be used in patients suffering from a severe kidney function impairment.

Use in elderly

This medicine should be used with caution in the elderly patients due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition.

Severe allergic reaction

Use of this medicine may cause severe and life-threatening allergic reactions in some patients. The use should be discontinued as early as possible in such cases and appropriate corrective measures should be initiated.

Gastrointestinal disorders

This medicine should be used with extreme caution in patients with a history of gastrointestinal disorders including gastric bleeding, ulceration, or blockage since it may worsen the patient's condition. This risk is especially higher if the patient is receiving other medicines which irritate the gastrointestinal tract (e.g. NSAIDs). Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Dexamethasone

Heparin

Celecoxib

Amlodipine

Albendazole

Cisplatin

Gentamicin

Estradiol

Prednisone

Paracetamol

Atorvastatin

Aspirin

Abciximab

Balsalazide

Antacids containing aluminum

Disease interactions

Bone Marrow Depression/Blood Dyscrasias

This medicine should be used with extreme caution in patients with a bone marrow disorder or an abnormal blood count due to the increased risk of worsening of the patient's condition. Use is not recommended if the platelet count is extremely low. Close monitoring of complete blood counts is recommended during therapy with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition.

Liver Disease

This medicine should be used with caution and monitoring in patients with mild to moderate impairment of normal liver function. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition. This medicine is not recommended for use in patients with a severe liver function impairment.

Kidney Disease

This medicine should be used with caution and monitoring in patients with mild to moderate impairment of normal kidney function. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition. This medicine is not recommended for use in patients with a severe kidney function impairment.

Gastrointestinal Disorders

This medicine should be used with caution in patients suffering from gastrointestinal diseases such as ulcers, hemorrhages, blockages, etc. due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the patient's condition.
Food interactions
Report the use of medical/non-medical caffeine to the doctor. Using caffeine or caffeine-containing products and this medicine may increase the risk of severe side effects. You may require a dose adjustment and more frequent clinical monitoring to safely use caffeine and this medicine together. Avoid or limit the use of caffeine-containing products during therapy with this medicine.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. You may be asked to undergo certain tests on a regular basis before and during the course of treatment with this medicine. Report any undesired side effects to your doctor. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine combines with the iron in the body and the complex thus formed in excreted in the urine.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Chelating agents

Schedule

Schedule H

[Internet]. Pharma.us.novartis.com. 2018 [cited 21 September 2018]. Available from:

https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/jadenu.pdf

[Internet]. Medicines.org.uk. 2018 [cited 21 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.4329.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 21 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021882s019lbl.pdf

Deferasirox [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 21 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Deferasirox

Deferasirox - DrugBank [Internet]. Drugbank.ca. 2018 [cited 21 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB01609

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Information on this page was last updated on 25 Sep 2018

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