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Combitide 500 Octacaps
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Combitide 500 Octacaps

Manufactured bySun Pharma Laboratories Ltd.
ContainsFluticasone propionate (500 mcg) + Salmeterol (50 mcg)
Description
Combitide 500 Octacaps is a combination of Fluticasone Propionate and Salmeterol. It is used in the treatment of chronic obstructive pulmonary disease (a group of lung conditions that cause blockage of airflow leading to breathing-related problems) and asthma (narrowing of the airways with excessive mucous production). It helps relieve symptoms such as wheezing, shortness of breath, chest tightness, breathing difficulty, coughing, etc. It works by relaxing and widening the muscles in your airways. Combitide 500 Octacaps may cause some side effects like sore throat, cough, headache, and hoarseness of voice. Inform your doctor if these side effects persist or become severe. Combitide 500 Octacaps should be used in the dose and duration advised by your doctor. For the ease of remembering, use it around the same time every day. Even if you see an improvement in your condition, do not stop using it. If you discontinue the use of this medicine early, your symptoms may reoccur. It should not be used to relieve sudden asthma attacks. Combitide 500 Octacaps should be avoided if you are allergic to it. Inform your doctor if you have liver or heart problems, diabetes, active infections, or any other medical conditions before starting the treatment. Consult your doctor if you are pregnant, planning a pregnancy, or are breastfeeding. This medicine is not recommended for use in children below 12 years of age.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Combitide 500 Octacaps

  • Blurred vision
  • Cough
  • Fever
  • Nausea
  • Headache
  • Runny Nose
  • Muscle pain
  • White patches in the mouth or on the tongue
  • Sore throat and hoarseness

Uses of Combitide 500 Octacaps

What is it prescribed for?

  • Asthma
  • Chronic obstructive pulmonary disease
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Combitide 500 Octacaps to show its effect is not clinically known.
  • How long do the effects of this medicine last?
    The amount of time for which Combitide 500 Octacaps remains active in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    Combitide 500 Octacaps has no habit-forming tendency.
  • Can this medicine be taken during pregnancy?
    Combitide 500 Octacaps is not recommended for use during pregnancy unless necessary. All the risks and benefits should be discussed with your doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    Combitide 500 Octacaps is not recommended for use while breastfeeding unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Allergy

Avoid using Combitide 500 Octacaps if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (of your face/tongue/throat), breathing difficulty, etc.

Status asthmaticus

Status asthmaticus is a severe form of asthma that is sudden and does not respond to standard treatments. These attacks can last for several minutes or even hours. Combitide 500 Octacaps is not recommended for use if you have status asthmaticus as it is not effective in treating this condition.
Warnings for special population

Pregnancy

Combitide 500 Octacaps is not recommended for use during pregnancy unless necessary. All the risks and benefits should be discussed with your doctor before using this medicine.

Breast-feeding

Combitide 500 Octacaps is not recommended for use while breastfeeding unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
General warnings

Hypokalaemia

Combitide 500 Octacaps may cause a decrease in blood potassium levels and lead to heart-related complications. Hence this medicine should be used with caution if you have hypokalaemia (low blood potassium levels).

Seizure disorder

Combitide 500 Octacaps should be used with caution if you have seizure disorders (sudden, uncontrolled brain activity causing fits) due to the increased risk of worsening your condition.

Use in children

Combitide 500 Octacaps is not recommended for use in children less than 12 years of age as the safety and efficacy data are not clinically established.

Missed Dose

If you miss a dose of Combitide 500 Octacaps, administer the missed dose as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment in case of an overdose of Combitide 500 Octacaps.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Atazanavir

Amprenavir

Itraconazole

Disease interactions

Cardiovascular disorders

Combitide 500 Octacaps should be used with caution if you have problems related to the heart and blood vessels. This medicine may cause an irregular heart rhythm, increased heartbeat, blood pressure changes, etc., leading to further complications.

Hyperadrenocorticism

Hyperadrenocorticism is a condition that occurs due to high levels of cortisol (a chemical substance that helps your body respond to stress, regulate blood sugar, and fight infections) in the body. High doses of Combitide 500 Octacaps should be used with caution as it may cause or worsen hyperadrenocorticism, in rare cases.

Infections

Combitide 500 Octacaps should be used with caution as it may decrease the immune response of the body and increase the risk of infections of the mouth and throat.

Ocular herpes infection

Ocular herpes simplex is an eye infection caused by the herpes simplex virus. Combitide 500 Octacaps should be used with caution if you have an ocular herpes infection. This medicine can damage the cornea (transparent front part of the eye) and worsen your condition.

Osteoporosis

Combitide 500 Octacaps should be used with caution if you have osteoporosis (a bone condition that causes loss of bone density leading to weak and brittle bones). It may cause loss of bone density and further worsen the existing condition.

Diabetes

Combitide 500 Octacaps should be used with caution if you have diabetes (increased blood sugar levels) as it may further increase the risk of elevated blood sugar levels.

Liver Disease

Combitide 500 Octacaps is broken down in the liver. An impaired liver may lead to an increased level of unused medicine in the blood, which may increase the risk of side effects. Hence, Combitide 500 Octacaps should be used with caution if you have liver problems.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Administer Combitide 500 Octacaps exactly as prescribed by your doctor. Follow all the instructions given on the information leaflet or the package insert. Do not use in larger or smaller amounts than prescribed. Do not stop the use of this medicine without consulting your doctor as it may worsen your condition. Consult your doctor if you experience any undesirable effects that persist or worsen. Combitide 500 Octacaps is not effective in treating an asthma attack that has already started. Always use a rescue inhaler to treat such symptoms. Consult your doctor to understand which medications to be used on a daily basis and which you should use if you have sudden breathing problems (asthma attacks).
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Combitide 500 Octacaps is a combination of Fluticasone Propionate and Salmeterol. Fluticasone propionate works by inhibiting the release of certain substances in the body that cause inflammation (swelling, redness, pain, etc.). Salmeterol relaxes and widens the blocked air passages leading to the lungs. This improves the amount of airflow to the lungs and makes breathing easier.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Inhaled corticosteroids, Long acting beta agonist

Schedule

Schedule H

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 6 December 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021077s029lbl.pdf>

Medicines.org.uk. 2021. AirFluSal Forspiro 50 microgram/500 microgram per actuation inhalation powder, pre-dispensed - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 6 December 2021].

https://www.medicines.org.uk/emc/product/4989/smpc>

Medicines.org.uk. 2021. [online] Available at: < [Accessed 6 December 2021].

https://www.medicines.org.uk/emc/files/pil.5504.pdf>

Drugs, H., 2021. Salmeterol Oral Inhalation: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 6 December 2021].

https://medlineplus.gov/druginfo/meds/a695001.html>

Drugs, H., 2021. Fluticasone Oral Inhalation: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 6 December 2021].

https://medlineplus.gov/druginfo/meds/a601056.html>
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Information on this page was last updated on 11 Jan 2022

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