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Combitide 50 Inhaler
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Combitide 50 Inhaler

Manufactured bySun Pharma Laboratories Ltd.
ContainsFluticasone propionate (50 mcg) + Salmeterol (25 mcg)
Description
Fluticasone propionate (50 mcg) + Salmeterol (25 mcg) is a combination medicine used to relieve symptoms such as shortness of breath, chest tightness, wheezing, coughing, etc.caused by asthma. This medicine is not recommended for use in patients less than 4 years of age. This medicine is used only for the maintenance treatment of asthma and is not useful for treating an acute, severe attack.
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Side effectsConcernsUsageRelated products

Substitutes

List of substitutes for Combitide 50 Inhaler

Digihaler SF 50 Inhaler
Glenmark Pharmaceuticals Ltd.
Flutrol 50 Inhaler
Macleods Pharmaceuticals Pvt. Ltd.

Side effects

Major & minor side effects for Combitide 50 Inhaler

  • Blurred vision
  • Chills
  • Cough
  • Difficulty in breathing
  • Fever
  • Nausea
  • Headache
  • Frequent urination
  • Vomiting
  • Runny Nose
  • Muscle pain
  • White patches in the mouth or on the tongue

Uses of Combitide 50 Inhaler

What is it prescribed for?

  • Asthma
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 20-30 minutes of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. If the medicine is used, the infant should be monitored closely for any undesirable side effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to salmeterol, fluticasone, any other corticosteroids, or any other inactive ingredients present along with these medicines.

Status asthmaticus

This medicine is not recommended for use in patients suffering from status asthmaticus (a severe, acute asthma attack) as a first-line therapy since it is not effective in treating this condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. If the medicine is used, the infant should be monitored closely for any undesirable side effects.
General warnings

Liver impairment

This medicine should be used with caution in patients with a known history of liver function impairment due to the increased risk of worsening of the patient's condition. Regular monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hypokalemia

This medicine should be used with caution in patients with a known history of hypokalemia (low blood potassium levels) due to the increased risk of worsening of the patient's condition. Close monitoring of potassium levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Seizure disorder

This medicine should be used with caution in patients with a known history of seizures due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Thyrotoxicosis or hyperthyroidism

This medicine should be used with caution in patients with a known history of thyrotoxicosis or hyperthyroidism due to the increased risk of worsening of the patient's condition. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition.

Use in pediatrics

This medicine is not recommended for use in patients less than 4 years of age since the safety and efficacy of use are not clinically established.

Growth retardation

This medicine may cause growth retardation in some children. Therefore, children receiving this medicine should be monitored closely with regard to growth parameters. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Candida infection

Patients using this medicine for extended periods of time should be examined for candida infection or any other signs of adverse effects on the oral mucosa. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Missed Dose

The missed dose should be inhaled as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Atazanavir

Amprenavir

Itraconazole

Mifepristone

Carvedilol

Clarithromycin

Labetalol

Disease interactions

Cardiovascular disorders

This medicine should be used with caution in patients with a known history of cardiovascular disorders due to the increased risk of serious adverse effects. Report any unusual symptoms to the doctor immediately. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.

Hyperadrenocorticism

This medicine should be used with caution in patients having a high level of adrenal hormones in the body due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Infections

This medicine should be used with extreme caution in patients with latent or active infections since this medicine can suppress the immune system and worsen the patient's condition. This risk is especially higher in patients on high doses of this medicine for a prolonged period of time. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Ocular herpes infection

This medicine should be used with caution in patients with an ocular herpes infection due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Ocular Toxicities

This medicine should be used with extreme caution in patients with a history of cataracts, glaucoma, or increased intraocular pressure due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Osteoporosis

This medicine should be used with caution in patients with osteoporosis since this medicine may cause loss of bone density and further worsen the existing condition. Close monitoring of bone density, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Hepatic impairment

This medicine should be used with caution in patients with liver function impairment due to the increased risk of severe adverse effects. Close monitoring of liver function may be required during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Diabetes

This medicine should be used with caution in patients suffering from diabetes due to the increased risk of altered blood glucose levels. You may require a dose adjustment and more frequent monitoring of blood glucose levels to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Use/Administer this medicine exactly as prescribed by your doctor. Follow all the instructions given in the information leaflet or the package insert. Do not use in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Fluticasone propionate works by inhibiting the release of certain substances in the body that cause inflammation (swelling, redness, pain, etc.). Salmeterol relaxes and opens the blocked air passages leading to the lungs; this improves the amount of airflow to the lungs and makes breathing easier. Their combination is thus more effective for the maintenance treatment of asthma.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Bronchodilator combinations

Schedule

Schedule H

[Internet]. Au.gsk.com. 2018 [cited 19 April 2018]. Available from:

https://au.gsk.com/media/223621/seretide_accuhaler_mdi_pi_006_approved.pdf

[Internet]. Hpra.ie. 2018 [cited 19 April 2018]. Available from:

https://www.hpra.ie/img/uploaded/swedocuments/2127063.PPA0465_091_006.176c0001-4efc-4e31-9ff5-de29b171aca3.000001Product%20Leaflet%20Approved.130403.pdf

[Internet]. Mhra.gov.uk. 2018 [cited 19 April 2018]. Available from:

http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1438325047644.pdf

Seretide 50 Evohaler - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 19 April 2018]. Available from:

https://www.medicines.org.uk/emc/product/3825/smpc

[Internet]. Medicines.org.uk. 2018 [cited 19 April 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.3825.pdf
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Information on this page was last updated on 4 Jul 2018

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