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Combimist Respules
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Combimist Respules

Manufactured byZydus Cadila
ContainsIpratropium (500 mcg) + Salbutamol (2.5 mg)
Description
Combimist Respules is a combination medicine which is used to relieve symptoms such as wheezing, shortness of breath, chest tightness, breathing difficulties, coughing, etc. caused by chronic obstructive pulmonary disease (COPD). This medicine is not recommended for use in patients less than 12 years of age.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Combimist Respules

  • Dizziness
  • Bladder pain
  • Wheezing
  • Nasal congestion
  • Blurred vision
  • Back pain
  • Nausea and Vomiting
  • Cough
  • Shaking and trembling of arms and feet
  • Irregular heartbeat
  • Difficulty in breathing
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Skin rash and spotting
  • Muscle pain and cramps
  • Sleep disturbances
  • Difficulty in passing urine
  • Headache

Uses of Combimist Respules

What is it prescribed for?

  • Chronic obstructive pulmonary disease
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1-3 minutes of an oral inhalation.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 4 to 12 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to salbutamol, ipratropium, atropine or its derivatives, or any other inactive ingredients present along with these medicines.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Driving vehicles and operating machinery

Use of this medicine may cause symptoms such as blurred vision, dizziness, drowsiness, confusion, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Glaucoma

This medicine should be used with caution in patients suffering from pre-existing glaucoma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Urinary Retention

This medicine should be used with caution in patients suffering from benign prostatic hyperplasia due to the increased risk of urinary retention. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in patients less than 12 years of age since the safety and efficacy of use are not clinically established.

Tachycardia

This medicine should be used with caution due to the increased risk of tachycardia (increased heart rate) and atrial fibrillation. Report any unusual symptoms such as changes in heart rate, palpitations, shortness of breath, dizziness, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This combination medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Other diseases

Report the past/present incidence of all diseases including heart and blood vessels disorders, electrolyte imbalances, any disease associated with thyroid and other glands, etc. to the doctor. All disease conditions should be considered before therapy with this medicine is initiated.

Hypokalemia

Use of this medicine may cause a decrease in blood potassium levels and hence, it should be administered with caution in patients suffering from hypokalemia. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Paradoxical bronchospasm

Use of this medicine has been associated with worsening of asthma symptoms in some instances. Contact your doctor immediately if breathing becomes more difficult after using this medicine. It is advised to discontinue this medicine immediately in such cases.

Excessive use

This medicine is strictly recommended for use in the prescribed quantities only; excessive use may cause severe adverse effects and may prove fatal in extremely rare cases.

Use in elderly

This medicine should be used with caution in the elderly as the risk of adverse effects are significantly high.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Atenolol

Ketoconazole

Mifepristone

Propranolol

Xylometazoline

Furosemide

Hydrochlorothiazide

Atropine

Insulin

Formoterol

Azithromycin

Aripiprazole

Clozapine

Chlorpheniramine

Tiotropium

Disease interactions

Renal Dysfunction

This medicine should be used with caution in patients with kidney disease due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver disease due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart disease

Use of this medicine has been associated with an increase in heart rate and changes in blood pressure. It should be used with caution in patients with an active or historic case of heart diseases. Patients should also be screened for the risk factors of heart disease before starting the treatment course. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Diabetes

Use of this medicine has been associated with a mild to moderate rise in blood sugar levels in most patients. Hence, caution should be exercised in patients with diabetes. Regular monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments of either this medicine or the anti-diabetic medicine or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypokalemia

Use of this medicine has been associated with a decrease in blood potassium levels (hypokalemia). Hence, it should be used with extreme caution in patients suffering from hypokalemia, a disorder where potassium levels in the body are very low. Regular monitoring of blood potassium levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Seizures

This medicine should be administered with caution in patients with seizure disorders since the risk of increased frequency and severity of convulsions is significantly high. Report any unusual symptoms to the doctor on priority. An alternative treatment option may be necessary in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Use this medicine exactly as prescribed. The prescribed frequency and duration of uptake are specific as per your needs. Do not use this medicine in larger or smaller quantities or for longer than recommended. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by relaxing and opening the blocked air passages leading to the lungs. It improves the amount of air flow to the lungs and makes breathing easier.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Bronchodilator combinations

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 13 August 2018]. Available from:

https://www.medicines.org.uk/emc/product/1423/smpc#

[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 13 August 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e0dee492-8bf9-4360-be9b-9d6ee1ecb256

[Internet]. Accessdata.fda.gov. 2018 [cited 13 August 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021527s021lbl.pdf

[Internet]. Dailymed.nlm.nih.gov. 2017 [cited 13 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=808e2b04-9e84-440a-b00e-2cbe858041da
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Information on this page was last updated on 15 Mar 2019

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