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Combimist Inhaler
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Combimist Inhaler

Manufactured byZydus Cadila
ContainsIpratropium (20 mcg) + Salbutamol (100 mcg)
Description
Combimist Inhaler is a combination of Ipratropium and Salbutamol. This medicine is used to relieve symptoms such as wheezing, shortness of breath, chest tightness, breathing difficulties, coughing, etc. caused by chronic obstructive pulmonary disease (lung disorder in which the airflow is blocked which leads to breathing difficulty). It works by relaxing and widening the muscles in your airways. Combimist Inhaler may cause some side effects like headache, cough, mouth dryness, nausea, constipation, etc. Inform your doctor if the side effects become severe or persist for a long time. Combimist Inhaler should be used in the dose and duration advised by your doctor. For the ease of remembering, use it around the same time every day. Even if you see an improvement in your condition, do not stop taking it. If you discontinue the use of this medicine early, your symptoms may return or worsen. Combimist Inhaler is not recommended for use in children less than 12 years of age. Inform your doctor about any other health issues like liver, kidney, heart troubles or if you are undergoing any medical treatment before taking this medicine. Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or are breastfeeding.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Combimist Inhaler

  • Headache
  • Dry mouth
  • Blurred vision
  • Back pain
  • Nausea and Vomiting
  • Cough
  • Irregular heartbeat
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Muscle pain and cramps
  • Sleep disturbances
  • Difficulty in passing urine

Uses of Combimist Inhaler

What is it prescribed for?

  • Chronic obstructive pulmonary disease
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required by Combimist Inhaler to show its effects is not clinically known.
  • How long do the effects of this medicine last?
    The time duration for which Combimist Inhaler remains in your body is four hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Combimist Inhaler.
  • Can this medicine be taken during pregnancy?
    Combimist Inhaler is not recommended for use in pregnant women unless absolutely necessary. However, consult your doctor if you are pregnant before using this medicine.
  • Can this medicine be taken while breast-feeding?
    Combimist Inhaler is not recommended for use in breastfeeding women unless absolutely necessary. Consult your doctor before using this medicine.

Allergy

Avoid taking Combimist Inhaler if you are allergic to it. Allergic reactions are very rare to this medicine. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (of your face/tongue/throat), breathing difficulties, etc.
Warnings for special population

Pregnancy

Combimist Inhaler is not recommended for use in pregnant women unless absolutely necessary. However, consult your doctor if you are pregnant before using this medicine.

Breast-feeding

Combimist Inhaler is not recommended for use in breastfeeding women unless absolutely necessary. Consult your doctor before using this medicine.
General warnings

Narrow-angle glaucoma

Narrow-angle glaucoma is a condition in which pressure inside your eyes increases. It happens due to fluid build-up caused by blocked drainage canals. Combimist Inhaler is not recommended in people with narrow-angle glaucoma as it may increase the risk of mydriasis (a condition in which the pupil of the eye gets widened due to increased eye pressure).

Urinary Retention

Urinary retention is a condition in which you are unable to empty your bladder (the organ in which the urine is stored) completely. Combimist Inhaler should be used with extreme caution if you have any urinary problems as this medicine can increase the risk of side effects such as urinary retention and urinary hesitancy.

Use in children

Combimist Inhaler is not recommended for use in children less than 12 years of age as the safety and efficacy of its use are not clinically established.

Other medicines

Combimist Inhaler may interact with many other medicines and may cause side effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Paradoxical bronchospasm

Paradoxical bronchospasm is a condition in which there is constriction of the airways due to the use of bronchodilator medicines (medicines that make breathing easier by relaxing the muscles in your lungs and widening the airways). Combimist Inhaler has been associated with worsening of asthma symptoms in some instances. Contact your doctor immediately if breathing becomes more difficult after using this medicine. It is advised to discontinue this medicine immediately in such cases.

Excessive use

Combimist Inhaler is strictly recommended for use in the prescribed quantities only; excessive use may cause side effects and may lead to a life-threatening condition.

Use in elderly

Combimist Inhaler should be used with caution in elderly people because the risk of side effects is significantly high.

Missed Dose

If you miss a dose of Combimist Inhaler, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact your doctor in case of an overdose of Combimist Inhaler.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Nortriptyline

Doxylamine

Disease interactions

Kidney Disease

Combimist Inhaler should be used with caution if you have a history of kidney problems. This medicine is excreted through urine. Using this medicine while you have kidney problems will lead to its accumulation. This can cause permanent damage to your kidneys and worsen your condition. Inform your doctor about your kidney problems.

Liver Disease

Combimist Inhaler should be used with extreme caution if you have a history of liver problems. This medicine breaks down in your liver and is excreted through urine. If you have a damaged liver, the medicine will get accumulated inside and lead to toxicity and can worsen your condition. Inform your doctor about any liver problems that you have.

Heart disease

Combimist Inhaler should be used carefully because it has been associated with an increase in heart rate and changes in blood pressure. If you have an active or history of heart problems, inform your doctor.

Diabetes

Combimist Inhaler may increase the blood sugar levels and worsen the symptoms of diabetes (a condition in which blood sugar level is increased). Use it carefully if you have diabetes.

Hypokalemia

Hypokalemia is a decrease in blood potassium levels. Use Combimist Inhaler with caution if you have a history of hypokalemia because it may worsen your condition.

Seizures

A seizure is a condition in which there is uncontrolled body movement due to an electrical disturbance in the brain. Combimist Inhaler should be used with caution if you have a history of seizures as it can lead to onset or aggravation of seizure attacks.
Food interactions
Information not available.
Lab interactions

N/A

Use of Combimist Inhaler may lead to positive results with respect to Salbutamol. People who are actively involved in sports need to be careful during intake of Combimist Inhaler.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Use Combimist Inhaler exactly as prescribed. The prescribed frequency and duration of uptake are specific as per your needs. Do not use this medicine in larger or smaller quantities or for longer than recommended. Consult your doctor if you experience any side effects. Do not stop the use of this medicine without consulting your doctor. Combimist Inhaler is only for inhalation. The tablet should not be swallowed. It is recommended to be taken every day at the same time. It does not act immediately and should not be used to treat short term respiratory problems.  It may cause mouth dryness. Use mouth rinses, maintain dental hygiene, increase water consumption, and consume sugarless sweets to avoid dry mouth. To avoid fungal infections in your mouth and throat, gargle with warm water after each inhalation. Take the initial dose of this medication under medical supervision because it might induce wheezing or tightness of the airways (bronchospasm) right after usage.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Combimist Inhaler works by relaxing and widening the blocked air passages of your lungs. It improves the amount of airflow to your lungs and makes breathing easier.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Bronchodilator combinations

Schedule

Schedule H

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 20 September 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021527s021lbl.pdf>

Medicines.org.uk. 2021. Ipratropium Bromide 250 micrograms/1ml Nebuliser Solution - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 16 September 2021].

https://www.medicines.org.uk/emc/product/3213/smpc>

Pubchem.ncbi.nlm.nih.gov. 2021. Salbutamol. [online] Available at: < [Accessed 21 September 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/2083>

Medicines.org.uk. 2021. Easyhaler Salbutamol 100mcg - Patient Information Leaflet (PIL) - (emc). [online] Available at: < [Accessed 21 September 2021].

https://www.medicines.org.uk/emc/product/6339/pil>
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Information on this page was last updated on 29 Sep 2021

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