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Comantrel Capsule

Manufactured byCONSERN PHARMA PVT. LTD.
ContainsAmantadine
Description

Comantrel Capsule is an antiviral medicine used in the treatment of infections caused by the influenza A virus. It is also used alone or in combination with other medicines to treat Parkinson's disease and Parkinson-like symptoms. These may include shakiness, stiffness, and slowness of movement. This medicine should be used with caution in patients with a known history of seizure disorders due to the increased risk of recurrent seizures.

Substitutes

List of substitutes for Comantrel Capsule

Amantrel 100 mg Capsule
Cipla Ltd.

Side effects

Major & minor side effects for Comantrel Capsule

  • Blurred vision
  • Confusion
  • Fainting
  • Pain and swelling of joint
  • Headache
  • Irritability
  • Loss of appetite
  • Nausea
  • Trouble sleeping

Uses of Comantrel Capsule

What is it prescribed for?

  • Influenza Prophylaxis
  • Influenza A infections
  • Parkinson's disease
  • Extrapyramidal Reaction
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to amantadine or any other inactive ingredient present in the formulation.

Narrow angle glaucoma

This medicine is not recommended for use in patients with a known history of untreated narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Compulsive Behaviors

This medicine should be used with caution due to the increased risk of impulsive or compulsive behaviors. These may include an intense urge to gamble, binge eat, or spend money. Close monitoring of the patients for any change in behavior and mood is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Hallucinations

This medicine should be used with caution due to an increased risk of severe side effects such as hallucinations, psychotic episodes, and confusion. This risk is especially higher in elderly patients. Close monitoring of patients for any changes in mood and behaviour is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor on priority. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery while taking this medicine.

Falling asleep during daily activities

This medicine should be used with caution due to the increased risk of side effects such as dizziness, fainting, and drowsiness. This may cause you to fall asleep during your day-to-day activities. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery while taking this medicine.

Hepatic and renal impairment

This medicine should be used with caution in patients with a known history of liver and kidney diseases due to the increased risk of severe side effects. Close monitoring of liver and kidney function may be necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Missed Dose

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clozapine

Dicyclomine

Doxepin

Loxapine

Azatadine

Disease interactions

Kidney disease

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Depression

This medicine should be used with extreme caution in patients with a known history of depression due to the increased risk of worsening of the patient's condition. Patients should be monitored closely for any changes in behavior and mood. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Psychosis

Comantrel Capsule is not recommended for use in patients with a known history of psychotic disorders due to the increased risk of worsening of the patient's condition. Close monitoring of the patients for any changes in behavior or mood may be necessary based on the clinical condition. Replacement with a suitable alternative may be required in some cases.

Hypotension

This medicine may increase the risk of orthostatic hypotension. This risk is especially higher in patients receiving high blood pressure medicines and elderly patients. Close monitoring of blood pressure may be necessary for such patients. Patients are advised to get up slowly from a sitting or a lying position to avoid fainting and falling. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Seizures

This medicine should be used with extreme caution in patients with a known history of seizure disorder due to the increased risk of recurrent seizures. Consult the doctor immediately in case of any unusual side effects. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that proper hygiene measures are adopted. Close monitoring of kidney function may be necessary during treatment with this medicine. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
This medicine blocks the influenza A virus from multiplying and stops the spread of the infection. It also increases the concentration of dopamine in the brain, dopamine is a natural substance that helps in relieving the symptoms of Parkinson's disease.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Adamantane antivirals, Dopaminergic Antiparkinsonism agents

Schedule

Schedule H

Amantadine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 5 June 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a682064.html

Amantadine - DrugBank [Internet]. Drugbank.ca. 2020 [cited 5 June 2020]. Available from:

https://www.drugbank.ca/drugs/DB00915

Amantadine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 5 June 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Amantadine

DailyMed - AMANTADINE capsule [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 5 June 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4157d9a7-a53f-4dde-b051-fe3e9a674913

[Internet]. Medsafe.govt.nz. 2020 [cited 5 June 2020]. Available from:

https://www.medsafe.govt.nz/Consumers/cmi/s/symmetrel.pdf
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Information on this page was last updated on 15 Jun 2020

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