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Cardules Plus 20 Capsule

Manufactured byABBOTT HEALTHCARE PVT LTD
ContainsAtenolol (50 mg) + Nifedipine (20 mg)
Description

Cardules Plus 20 Capsule is a combination medicine used for the treatment of mild to moderate hypertension (high blood pressure) and to prevent chest pain (angina). Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect. This medicine is not recommended for use in patients less than 18 years of age.

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Side effects

Major & minor side effects for Cardules Plus 20 Capsule

  • Blurred vision
  • Difficulty in breathing
  • Sweating
  • Cold hands or feet
  • Anxiety
  • Chest pain
  • Dizziness
  • Decrease in frequency of urination
  • Increased thirst
  • Loss of appetite
  • Trouble sleeping
  • Diarrhea
  • Swelling of the face, arms, hands, lower legs, or feet
  • Headache
  • Muscle cramps
  • Shakiness in the legs, arms, hands, or feet
  • Chest congestion
  • Irregular breathing
  • Pale skin
  • Nausea or vomiting
  • Belching
  • Indigestion
  • Abnormal ejaculation

Uses of Cardules Plus 20 Capsule

What is it prescribed for?

  • Hypertension
  • Angina pectoris
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 12 to 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as a headache, dizziness, lightheadedness, fainting, changes in pulse or heart rate, etc. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to atenolol, any other beta blockers, nifedipine, any other medicines belonging to the dihydropyridines class of drugs, or any other inactive ingredients present along with these medicines.

Cardiogenic shock

This medicine is not recommended for use in patients suffering from a cardiogenic shock due to the increased risk of worsening of the patient’s condition.

Heart block greater than first degree

This medicine is not recommended for use in patients suffering from a heart block greater than first degree due to the increased risk of worsening of the patient’s condition.

Sick sinus syndrome

This medicine is not recommended for use in patients suffering from sick sinus syndrome or sinus bradycardia due to the increased risk of worsening of the patient’s condition.

Uncompensated cardiac failure

This medicine is not recommended for use in patients with uncompensated cardiac failure due to the increased risk of worsening of the patient’s condition.

Severe pulmonary edema

This medicine is not recommended for use in patients with severe pulmonary edema due to the increased risk of worsening of the patient’s condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (creatinine clearance < 15 mL/min/1.73 m2, GFR < 30 ml/min, serum creatinine > 600 mmol/L) due to the increased risk of worsening of the patient’s condition.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient’s condition.

Aortic stenosis

This medicine is not recommended for use in patients with aortic stenosis due to the increased risk of worsening of the patient’s condition.

Pheochromocytoma

This medicine is not recommended for use in patients with an untreated pheochromocytoma due to the increased risk of worsening of the patient’s condition.

Hypotension

This medicine is not recommended for use in patients suffering from hypotension (low blood pressure levels) due to the increased risk of worsening of the patient’s condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Cardiac Failure

This medicine may cause heart failure and reduced blood flow in patients suffering from heart diseases. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Major surgery

This medicine should be used with caution in patients who are scheduled to undergo major surgery. An anesthetic agent with little negative inotropic activity should be selected to minimize the adverse effect on the heart.

Lung Diseases

This medicine should be used with caution in patients suffering from lung diseases who do not respond to other antihypertensive medications. Start with the lowest possible dose and increase the dose based on the clinical condition. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may alter the serum lipid levels. Regular monitoring of lipid profile tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Sports

Athletes are advised not to indulge in certain sports while using this medicine. Archery, racing, shooting and other high-risk sports should be avoided. Sportspersons should refer to the list of medicines published by World Anti-Doping Agency (WADA) which are not to be taken while participating in specific sports events.

Hyperthyroidism

Use of this medicine should be done with caution in patients with thyroid disorders since it may mask the symptoms of hyperthyroidism. Regular monitoring of the thyroid function tests is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Hypotension

Use of this medicine may increase the risk of hypotension (very low blood pressure levels), especially in patients with volume depletion. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Myocardial infarction or angina

This medicine should be used with caution while starting or increasing the dose in patients with coronary artery diseases since it may worsen the symptoms of myocardial infarction or angina.

Liver Diseases

This medicine should be used with caution in patients with mild to moderate liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients suffering from severe liver function impairment.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Tuberculosis

Patients suffering from tuberculosis and undergoing therapy with rifampicin or rifampin are advised not to undergo therapy with this medicine since rifampicin or rifampin will reduce the effectiveness of this medicine. Your doctor may prescribe a suitable alternative based on your clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as a headache, dizziness, lightheadedness, fainting, changes in pulse or heart rate, etc. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Alprazolam

Carbamazepine

Dexamethasone

Diltiazem

Itraconazole

Rifampicin

Theophylline

Diclofenac

Disease interactions

Asthma

This medicine is not recommended for use in patients with severe asthma due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. An alternative treatment option may be necessary in some cases based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients suffering from glaucoma since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Diabetes

This medicine should be used with caution in patients suffering from diabetes since it may mask symptoms of hypoglycemia such as tremors, tachycardia, and blood pressure changes. Regular monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine since it may increase the undesired side effects associated with it. Inform the doctor if you experience any signs and symptoms such as dizziness, headache, swelling of hands and feet, etc.
The desired effect of this medicine will not be achieved if it is taken together with multivitamin with minerals. You may require a dose adjustment and more frequent clinical monitoring to safely use these medicines together. Do not stop the use of any medicine without consulting your doctor.
Avoid consumption of large amounts of orange juice with this medicine since it may decrease the effectiveness of the medicine.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Atenolol relaxes the blood vessels and reduces the heart rate, promoting a smooth flow of the blood. Nifedipine works by inhibiting the influx of calcium into the muscles and causes relaxation of the muscles.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antihypertensive combinations, Beta blockers with calcium channel blockers, Cardioselective beta blockers, Calcium channel blocking agents

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 22 October 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.5496.pdf

DailyMed - Atenolol- atenolol tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 10 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f36d4ed3-dcbb-4465-9fa6-1da811f555e6

[Internet]. 2017 [cited 10 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/25739

DailyMed - Nifedipine capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 30 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0cc236dc-95fa-49cc-aeb8-6590de157585

Tenif 50 mg/20 mg Capsules - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 14 February 2019]. Available from:

https://www.medicines.org.uk/emc/product/5496/smpc
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Information on this page was last updated on 15 Feb 2019

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