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Megapen 1 g Injection
Manufactured byARISTO PHARMACEUTICALS PVT LTD
ContainsAmpicillin (500 mg) + Cloxacillin (500 mg)
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Description
Megapen 1 g Injection is a combination medicine which may be used for the treatment of respiratory tract infections, osteomyelitis, septicemia, post-operative wound infections, etc caused by the susceptible bacteria. This medicine is not recommended for treating common cold, flu or other viral infections since it is not effective in treating them.
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Substitutes
List of substitutes for Megapen 1 g Injection
Side effects
Major & minor side effects for Megapen 1 g Injection
Nausea or Vomiting
Diarrhea
Skin Rash
Pain at the injection site
Abdominal pain
Yellowing of skin and eyes
Fever with chills
Dizziness
Uses of Megapen 1 g Injection
What is it prescribed for?
Respiratory Tract Infection
This medicine may be used in the treatment of respiratory tract infections like pneumonia and bronchitis, caused by susceptible strains of bacteria.
Bacterial Septicemia
This medicine may be used in the treatment of Septicemia which is an infection of the blood caused by susceptible strains of bacteria.
Osteomyelitis (Infection of bone)
This medicine may be used for the treatment of osteomyelitis, an infection of the bones caused by bacteria. This generally occurs in the legs, arms, or spine.
Post operative infections
This medicine may be used for the treatment of a post-operative wound or pulmonary infections caused by susceptible strains of bacteria.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The amount of time required for this medicine to show its action is not clinically established.How long do the effects of this medicine last?
The amount of time for which this medicine remains active in the body is not clinically established.Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is this a habit forming medicine?
No habit-forming tendencies were reported.Can this medicine be taken during pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.Can this medicine be taken while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.
Allergy
This medicine is not recommended for use in patients with a known allergy to ampicillin, cloxacillin, other antibiotics of the penicillin or cephalosporin group, or any other inactive ingredients present in the formulation.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.
General warnings
Drug-resistance
Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.
Clostridium difficile-associated diarrhea
Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of bacteria called Clostridium difficile and you may experience severe diarrhea as a result. Report any such incidence to the doctor on priority and avoid usage of this medicine in such cases.
Hypersensitivity reactions
This medicine may cause serious and occasionally fatal hypersensitivity reactions including anaphylactic shock in some patients. This risk is especially high in patients with a history of sensitivity to multiple allergens. If an anaphylactic reaction occurs, the treatment should be discontinued immediately and appropriate corrective measures should be undertaken.
Driving or Operating machinery
Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Missed Dose
Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.
Overdose
Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Live cholera vaccine
Chloramphenicol
Methotrexate
Tetracycline
Warfar
Disease interactions
Kidney Disease
This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Bone Marrow Depression
This medicine should be used with caution in patients with bone marrow depression due to the increased risk of worsening of the patient's condition. Close monitoring of blood counts is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Colitis
This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesired side effects to the doctor promptly.
Miscelleneous
How it works
This medicine works by interfering with certain processes that help the bacteria to form new cell walls. This helps in stopping the growth and multiplication of bacteria and eventually kills them.
Legal Status
Classification
Category
Aminopenicillins, Penicillinase resistant penicillins
Schedule
Schedule H
DailyMed - Ampicillin sodium injection, powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 30 March 2017]. Available from:
Ampicillin Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 30 March 2017]. Available from:
Cloxacillin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 16 March 2018]. Available from:
[Internet]. Pdf.hres.ca. 2018 [cited 16 March 2018]. Available from:
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Information on this page was last updated on 25 Jul 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.