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Maczone Plus 750 Injection
Manufactured byMACLEODS PHARMACEUTICALS PVT.LTD
ContainsCeftriaxone (500 mg) + Sulbactam (250 mg)
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Description
Maczone Plus 750 Injection is a combination medicine used for the treatment of infections of the lower respiratory tract, ears, skin and skin structure, etc. caused by susceptible bacteria. This medicine is not recommended for use in patients less than 28 days of age (neonates).
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Substitutes
List of substitutes for Maczone Plus 750 Injection
Side effects
Major & minor side effects for Maczone Plus 750 Injection
Diarrhea
Nausea and Vomiting
Itching
Fatigue
Chills
Edema
Black or tarry stools
Chest pain
Fever
Difficult or painful urination
Sore throat
Abdominal pain
Dizziness
Swelling of face, lips, eyelids, tongue, hands and feet
Acid or sour stomach
Change in taste
Excessive air or gas in stomach
Uses of Maczone Plus 750 Injection
What is it prescribed for?
Bacterial infections
This medicine is used for the treatment of infections caused by susceptible bacterial species that are resistant to commonly-used systemic antibiotics or ceftriaxone alone. These infections may include urinary tract infections, bone and joint infections, intra-abdominal infections, bacterial septicemia, pelvic inflammatory disease, etc.
Bacterial Meningitis
This medicine is used in the treatment of meningitis, which is an inflammation of the protective membranes that surround the brain and spinal cord. This infection may be caused by Streptococcus pneumoniae or Neisseria meningitidis.
Skin and Skin Structure Infection
This medicine is used in the treatment of infections of the skin and skin structures caused by susceptible bacteria. These infections may include infected wounds, folliculitis, abscesses, cellulitis, ulcers, etc.
Acute bacterial otitis media
This medicine is used in the treatment of an acute middle ear infection (otitis media) which may be caused by bacteria such as Streptococcus pneumoniae, Haemophilus parainfluenzae, etc.
Lower Respiratory Tract Infection
This medicine is used in the treatment of lower respiratory tract infections such as pneumonia caused by susceptible species of bacteria.
Surgical prophylaxis
This medicine is used prior to a surgical procedure to prevent post-surgical bacterial infections.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The effect of this medicine occurs rapidly after an intravenous or intramuscular administration.How long do the effects of this medicine last?
The amount of time for which this medicine remains active in the body is not clinically established.Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is this a habit forming medicine?
No habit-forming tendencies were reported.Can this medicine be taken during pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.Can this medicine be taken while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to ceftriaxone, sulbactam, any other beta-lactam antibiotics, or any other inactive ingredients present along with these medicines.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings
Renal impairment
This medicine should be used with caution in patients with a known history of renal function impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Prothrombin time
Alterations in prothrombin time (a test used to check for bleeding problems) have been reported in patients receiving this medicine. Regular monitoring of prothrombin time may be necessary for some patients. Replacement with a suitable alternative may be required in some cases based on the clinical condition.
Drug-resistance
Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.
Clostridium difficile-associated Diarrhea
Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of a bacteria called Clostridium difficile and you may experience severe diarrhea as a result. Report any such incidence to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Use in neonates
This medicine is not recommended for use in patients less than 28 days of age since the safety and efficacy of use are not clinically established.
Hepatic impairment
This medicine should be used with caution in patients with liver function impairment due to the increased risk of worsening of the patient's condition. Regular monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Electrolyte imbalance
This medicine should be used with caution in patients with a known history of electrolyte imbalance since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of electrolyte levels, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Missed Dose
Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.
Overdose
Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Ethinyl Estradiol
Cholera Vaccine
Amikacin
Probenecid
Cyclosporine
Disease interactions
Renal impairment
This medicine should be used with caution in patients with a known history of renal diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Gastrointestinal Diseases
This medicine should be used with caution since it may cause diarrhea, abdominal pain, and blood in stools in some cases. This risk is especially higher in patients with a history of gastrointestinal diseases, particularly colitis. Report any such symptoms to the doctor immediately. Replacement with a suitable alternative may be required in some cases based on the clinical condition.
Seizure disorders
This medicine should be used with caution in patients with a history of seizure disorder or a family history of seizures since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesirable side effects to the doctor promptly.
Miscelleneous
How it works
Ceftriaxone works by interfering with certain processes that help the bacteria to grow and increase in number. Sulbactam inhibits some chemicals produced by the bacteria and makes the bacteria more sensitive to ceftriaxone activity. Their combination thus becomes effective against an extended range of bacteria.
Legal Status
Classification
Category
Third generation cephalosporins, Beta-lactamase inhibitors
Schedule
Schedule H
Cefossin [Internet]. Biotavia.com. 2018 [cited 29 March 2018]. Available from:
Blue Cross Laboratories Pvt Ltd. - World Class Quality Medicines At Affordable Prices [Internet]. Bluecrosslabs.com. 2018 [cited 29 March 2018]. Available from:
[Internet]. CiplaMed. 2018 [cited 19 March 2018]. Available from:
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Information on this page was last updated on 5 Jul 2018
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.