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Maczone Plus 375 Injection
Manufactured byMACLEODS PHARMACEUTICALS PVT.LTD
ContainsCeftriaxone (250 mg) + Sulbactam (125 mg)
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Description
Maczone Plus 375 Injection is an antibiotic with the combination of Ceftriaxone and Sulbactam. It is used to treat bacterial infections affecting the lungs, nose, throat, ears, urinary tract etc. This medicine kills or stops the growth of bacteria causing the infection. Maczone Plus 375 Injection is not effective against infections caused by viruses.
Maczone Plus 375 Injection shows side effects like diarrhoea, pain at the injection site, headache, weakness, and dizziness. Do not use this medicine if you are allergic to it. Contact your doctor if any side effects are seen for a long time.
Maczone Plus 375 Injection is injected into your vein or muscle by a healthcare professional in a hospital or clinic. Do not inject it on your own. Your doctor will determine the dose you need each day and how often the injections should be given. Once an antibiotic is started, it is always recommended to finish the entire course of treatment.
Maczone Plus 375 Injection may interact with calcium-containing products. Hence avoid using this medicine in infants and neonates (babies less than 28 days old) receiving calcium products. Inform your doctor if you have any liver, kidney or stomach and intestinal problems before taking the medicine.
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Substitutes
List of substitutes for Maczone Plus 375 Injection
Side effects
Major & minor side effects for Maczone Plus 375 Injection
Diarrhoea
Nausea and Vomiting
Itching
Tiredness
Chills
Black or tarry stools
Fever
Difficult or painful urination
Sore throat
Abdominal pain
Dizziness
Swelling of face, lips, eyelids, tongue, hands and feet
Acid or sour stomach
Change in taste
Excessive air or gas in stomach
Headache
Uses of Maczone Plus 375 Injection
What is it prescribed for?
Urinary tract infection
An infection in any part of your urinary system- the kidneys, bladder, ureters, or urethra is called urinary tract infections (UTIs). UTIs can occur as complicated or uncomplicated urinary tract infections. Woman are at a greater risk of getting this infection compared to men. Maczone Plus 375 Injection is used to treat complicated and uncomplicated urinary tract infections caused by bacteria.
Bacterial Meningitis
Bacterial meningitis is an infection of the meninges, the protective layer that surrounds the brain and spinal cord. It starts when bacteria reach to your bloodstream and travel to your brain and spinal cord. Maczone Plus 375 Injection is used to treat bacterial meningitis.
Skin and Skin Structure Infection
Skin and soft tissue infections occur when the bacteria invade the skin and its supporting structures. Maczone Plus 375 Injection is used to treat all skin infections including abscess (collection of pus) caused by bacteria.
Acute bacterial otitis media
Acute otitis media (AOM), is an infection of the middle ear (the area behind the eardrum), common in infants and young children. Maczone Plus 375 Injection is used to treat acute otitis media caused by bacteria.
Lower Respiratory Tract Infection
Maczone Plus 375 Injection is used to treat the following lung infections:
1. Pneumonia- It is an infection of the air sacs in the lungs (either single or both lungs). It can be caused due to bacteria or virus. This medicine is used to treat pneumonia caused by bacteria.
2. Bronchitis- It is the swelling and irritation of bronchial tubes that regulates air passage in the lungs. It is used to treat bronchitis caused by bacteria.
Gonococcal Infection
Gonorrhoea is a sexually transmitted infection (STI) caused by the bacteria Neisseria gonorrhoea. It infects both men and women. It spreads during vaginal, oral or anal sex, especially sex without protection. Maczone Plus 375 Injection is used to treat a gonococcal infections.
Intra-abdominal Infection
Intra-abdominal infection (IAI) describes a number of infections. It includes peritonitis (swelling of the peritoneum-lining of the abdominal wall), pancreatitis (swelling of the pancreas- an organ located behind the lower part of the stomach), diverticulitis (swelling of diverticula, one or more small pouches in the intestine), cholecystitis (swelling of the gallbladder, a digestive organ that sits just under the liver), and cholangitis (swelling of the bile duct system). Maczone Plus 375 Injection is used to treat infections occurring within the abdomen (belly region) caused by bacteria.
Pelvic inflammatory disease
Pelvic inflammatory disease is an infection of the female reproductive organs caused by bacteria like Chlamydia trachomatis, Neisseria gonorrhoea, etc. In this infection, the bacteria first enter the vagina and move into the pelvic organs like fallopian tubes, ovaries, cervix, and the uterus, thus spreading the infection. Maczone Plus 375 Injection is used to treat pelvic inflammatory disease.
Surgical prophylaxis
Maczone Plus 375 Injection is used prior to a surgical procedure and after surgery to prevent bacterial infections.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The effect of Maczone Plus 375 Injection starts immediately after the intravenous or intramuscular administration.How long do the effects of this medicine last?
It is no know how long the effect of Maczone Plus 375 Injection lasts in your body.Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is this a habit forming medicine?
No habit-forming tendencies were reported for Maczone Plus 375 Injection.Can this medicine be taken during pregnancy?
Maczone Plus 375 Injection may be safe for use in pregnancy to treat bacterial infections. Animal studies indicate no risk to the foetus however, data on human studies are not available. Therefore, use Maczone Plus 375 Injection only upon your doctor's recommendation.Can this medicine be taken while breast-feeding?
Maczone Plus 375 Injection should be used while breastfeeding only if absolutely necessary. You should hold feeding until you complete the treatment course. Observe your baby for any side effects like diarrhoea and rashes.
Allergy
Avoid using Maczone Plus 375 Injection if you are allergic to it. Inform your doctor if there is any history of allergy to Maczone Plus 375 Injection. If you notice any symptoms such as skin rashes, itching/swelling anywhere on your body, dizziness, breathing difficulty, etc. inform your doctor and seek immediate medical attention.
Warnings for special population
Pregnancy
Maczone Plus 375 Injection may be safe for use in pregnancy to treat bacterial infections. Animal studies indicate no risk to the foetus however, data on human studies are not available. Therefore, use Maczone Plus 375 Injection only upon your doctor's recommendation.
Breast-feeding
Maczone Plus 375 Injection should be used while breastfeeding only if absolutely necessary. You should hold feeding until you complete the treatment course. Observe your baby for any side effects like diarrhoea and rashes.
General warnings
Prothrombin time
There may be alterations in prothrombin time (a test used to check for bleeding problems) while receiving Maczone Plus 375 Injection. Regular monitoring of prothrombin time and Vitamin K administration may be necessary, especially if you have low vitamin K levels, are malnourished, or have liver problems.
Antibiotic resistance
Antibiotic resistance occur when bacteria develops the ability to defeat the medicine that was intended to kill them. Hence to avoid such resistance, you should always complete the entire course of treatment with Maczone Plus 375 Injection even if you fell better after a few doses.
Diarrhoea
Maczone Plus 375 Injection can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Inform your doctor if you experience severe diarrhoea while receiving this medicine.
Use in neonates
Maczone Plus 375 Injection is not recommended for use in infants less than 28 days of age since the safety and efficacy of use are not clinically established.
Liver diseases
Maczone Plus 375 Injection may increase your liver enzymes and cause liver damage. It is recommended that you regularly monitor the liver enzyme levels while on treatment with Maczone Plus 375 Injection and even after treatment with this medicine is complete.
Driving or operating machines
Maczone Plus 375 Injection may cause dizziness. Hence, do not perform activities that require mental attention and focus such as driving vehicles or operating machines.
Missed Dose
Since Maczone Plus 375 Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.
Overdose
Since Maczone Plus 375 Injection is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Amikacin
Probenecid
Ethinyl Estradiol
Cyclosporine
Cholera Vaccine (live)
Disease interactions
Renal impairment
Maczone Plus 375 Injection is filtered by the kidney and moved out of the body through urine. If you have any medical conditions that affect the kidneys, this medicine has to be used with caution as it may damage your kidneys further.
Gastrointestinal Diseases
Maczone Plus 375 Injection can kill the helpful bacteria in your stomach or intestine and causes diarrhoea. Therefore use this medicine with extreme caution if you have any stomach and intestinal problems, particularly colitis (inflammation of the large intestine), as it may worsen your health condition.
Seizure disorders
Seizure disorder (fits) is a condition due to uncontrolled electrical activity between brain cells that causes temporary abnormalities in muscle tone and movements, behaviour, etc. Avoid using Maczone Plus 375 Injection if you have a history of seizure episodes, as it can worsen your health condition. Your doctor may adjust the dose or replace the medicine with a safer alternative as required.
Food interactions
Information not available.
Lab interactions
Information not available.
Maczone Plus 375 Injection is for parenteral use. It should be administered by a qualified healthcare professional in a clinical or hospital setting. Your doctor will determine an appropriate dosage based on your clinical condition. Report any undesirable side effects to the doctor promptly.
You should not administer Maczone Plus 375 Injection on your own. Never stop your medication before the prescribed treatment course even if you feel better, as it can worsen your infection. Tell your doctor about the medicines you are taking as well as your medical conditions before receiving Maczone Plus 375 Injection.
Miscelleneous
How it works
Maczone Plus 375 Injection is a combination of Ceftriaxone and Sulbactam.
Ceftriaxone works by preventing the formation of bacterial cell walls. This helps in stopping the growth and multiplication of the bacteria and eventually kills them.
Sulbactam inhibits some chemicals produced by the bacteria and makes them more sensitive to ceftriaxone activity.
Legal Status
Classification
Category
Third generation cephalosporins, Beta-lactamase inhibitors
Schedule
Schedule H
Pubchem.ncbi.nlm.nih.gov. 2021. Ceftriaxone. [online] Available at: < [Accessed 1 June 2021].
Pubchem.ncbi.nlm.nih.gov. 2021. Sulbactam. [online] Available at: < [Accessed 1 June 2021].
PHARMA, Q., 2021. Ceftriaxone and Sulbactam For Injection Taj Pharma SmPC. [online] Issuu. Available at: < [Accessed 6 August 2021].
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Information on this page was last updated on 14 Sep 2021
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.