✕
Free ₹200 worth HealthCash on app
Use HealthCash to order medicines, health products & much more
Isolazine Tablet
Manufactured byLupin Ltd.
ContainsIsosorbide Dinitrate (20 mg) + Hydralazine (37.5 mg)
CURRENTLY UNAVAILABLE
Confused about any medicine? Just ask Practo AIFREE
50000+ health queries resolved in last month
Chat with Practo AI on Whatsapp
Not finding what you need? Ask Practo AI
FREE
Chat with Practo AI on Whatsapp
Description
Isolazine Tablet is used in the prevention of angina (chest pain that occurs when your heart muscle does not get a sufficient amount of oxygen-rich blood). Angina is caused due to the narrowing of blood vessels that carries blood to your heart. This medicine relaxes the blood vessels and also decreases the pressure on your heart. Thus, it allows the blood to flow easily to your heart.
Isolazine Tablet shows side effects like headache, flushing (redness of the face or neck), low blood pressure, change in the heartbeat, etc. It may also cause dizziness in some cases. Avoid driving vehicles or operating machines if you feel dizzy after taking this medicine.
Isolazine Tablet may be taken on an empty stomach. Your doctor will decide the dose and duration of treatment based on your medical condition. Do not stop taking this medicine on your own, as your symptoms may get worse, especially if you stop taking it suddenly. Isolazine Tablet may not work well when used for a long time. Hence, consult your doctor if your symptoms occur more often or become worse.
Isolazine Tablet is not recommended for use if you are allergic to it. Use this medicine with caution if you have any medical condition affecting your liver, kidney, heart, eyes, etc. Inform your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
QUICK LINKS:
Substitutes
List of substitutes for Isolazine Tablet
Side effects
Major & minor side effects for Isolazine Tablet
Irregular heartbeat
Low blood pressure
Dizziness
Headache
Nausea or Vomiting
Difficulty in breathing
Flushing or redness of skin
Weakness
Uses of Isolazine Tablet
What is it prescribed for?
Angina pectoris
Angina pectoris refers to chest pain that occurs due to the reduced flow of blood to the heart. Isolazine Tablet is used for the prevention of angina. Only the sublingual tablet (placing a tablet under your tongue) may be used to treat an angina attack that has already begun.
Chronic heart failure
Heart failure is a condition in which the heart cannot pump enough blood to meet the demand of the body. Isolazine Tablet may be used as an adjunct treatment (additional treatment) in the management of severe heart failure.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
Isolazine Tablet may start to show its action within 1 hour.How long do the effects of this medicine last?
The effect of Isolazine Tablet may last for an average duration of 4-6 hours.Is it safe to consume alcohol while taking this medicine?
Consumption of alcohol is not recommended during treatment with Isolazine Tablet as it may increase the risk of dizziness, lightheadedness, etc. Avoid performing activities that require high mental alertness like driving vehicles or operating machines while you are taking this medicine.Is this a habit forming medicine?
Isolazine Tablet has no habit-forming tendency.Can this medicine be taken during pregnancy?
Isolazine Tablet is not recommended for use during pregnancy unless necessary. Discuss the risks and benefits with your doctor before taking this medicine.Can this medicine be taken while breast-feeding?
Isolazine Tablet is not recommended for use while breastfeeding unless necessary. Discuss the risks and benefits with your doctor before taking this medicine.
Allergy
Avoid taking Isolazine Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Anaemia
Isolazine Tablet is not recommended for use if you have severe anaemia (low levels of haemoglobin in the blood) due to the increased risk of worsening your condition.
Hypertrophic obstructive cardiomyopathy
Hypertrophic obstructive cardiomyopathy is a heart condition in which the heart muscle becomes abnormally thick. Isolazine Tablet is not recommended for use if you have hypertrophic obstructive cardiomyopathy as it may further worsen your condition.
Head trauma/ Increased intracranial pressure
Intracranial hypertension refers to increased pressure around the brain. Isolazine Tablet is not recommended for use if you recently had a severe head injury or have intracranial hypertension. This medicine may increase the pressure within the skull and further worsen your condition.
Medicine for erectile dysfunction
Isolazine Tablet is not recommended for use if you are taking medicines such as Sildenafil, Tadalafil, or Vardenafil for the treatment of erectile dysfunction (inability to get or keep an erection firm enough for sexual intercourse in men). Combined use of these medications may cause low blood pressure.
Warnings for special population
Pregnancy
Isolazine Tablet is not recommended for use during pregnancy unless necessary. Discuss the risks and benefits with your doctor before taking this medicine.
Breast-feeding
Isolazine Tablet is not recommended for use while breastfeeding unless necessary. Discuss the risks and benefits with your doctor before taking this medicine.
General warnings
Withdrawal symptoms
Abrupt discontinuation of Isolazine Tablet may increase the risk of side effects. A gradual dose reduction may be required to avoid such reactions. Do not stop the use of this medicine without consulting your doctor.
Driving and operating machines
Isolazine Tablet may cause symptoms such as dizziness, lightheadedness, weakness, low blood pressure, etc. in some cases. If you experience any of these symptoms, avoid performing activities such as driving vehicles or operating machines.
Use in children
Isolazine Tablet is not recommended for use in children less than 18 years of age as the safety and efficacy data are not clinically established.
Missed Dose
Take the missed dose of Isolazine Tablet as soon as you remember. If it is time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Never take more than the prescribed dose. Seek emergency medical treatment if you suspect an overdose of Isolazine Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended during treatment with Isolazine Tablet as it may increase the risk of dizziness, lightheadedness, etc. Avoid performing activities that require high mental alertness like driving vehicles or operating machines while you are taking this medicine.
Interaction with Medicine
Amitriptyline
Riociguat
Alprazolam
Flurazepam
Baclofen
Alteplase
Disease interactions
Heart Disease
Isolazine Tablet should be avoided if you have an acute myocardial infarction (a serious condition that occurs due to the death of the heart muscle when blood flow to the heart decreases or stops) or congestive heart failure (a condition where the heart cannot pump enough blood to meet the body's demand). If this medicine is recommended in such conditions, your doctor may periodically monitor the functioning of your heart.
Hypotension
Isolazine Tablet may cause hypotension (low blood pressure). Hence, this medicine should be used with caution if you have hypotension. Your doctor may monitor your blood pressure closely while you are taking this medicine.
Glaucoma
Glaucoma is a condition in which the optic nerve (the nerve connecting the eye to the brain) is damaged, usually due to high pressure within your eyeballs. Isolazine Tablet should be used with caution if you have glaucoma as it may increase the pressure inside the eyes and worsen your condition.
Liver Disease
Isolazine Tablet is broken down in the liver. Hence, this medicine should be used with caution if you have severe liver problems as it may increase the risk of accumulation of this medicine in the liver.
Kidney Disease
Isolazine Tablet is excreted by kidneys. If you have kidney problems, it may alter the excretion process and increase the risk of accumulation of this medicine in the kidneys. Thus, this medicine should be used with caution if you have severe kidney problems.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Isolazine Tablet on an empty stomach or as instructed by your doctor.
Isolazine Tablet may cause a fall in blood pressure and make you feel dizzy, especially while getting up from a lying or sitting position.
Avoid consuming alcohol during treatment with this medicine as it may increase the risk of dizziness and lightheadedness.
Avoid taking medications like Sildenafil or Tadalafil (medicines prescribed for erectile dysfunction) while on treatment with this medicine as it may cause low blood pressure.
Miscelleneous
How it works
Isolazine Tablet works by relaxing the blood vessels and reducing the strain on the heart.
Legal Status
Classification
Category
Antianginal agents
Schedule
Schedule H
Medicines.org.uk. 2021. Isosorbide Dinitrate Tablets BP 10mg - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: [Accessed 19 October 2021].
Stewart, M., 2021. Isosorbide dinitrate side-effects & dosage info. [online] Patient.info. Available at: o/medicine/isosorbide-dinitrate-isoket-retard [Accessed 19 October 2021].
Accessdata.fda.gov. 2021. [online] Available at: [Accessed 19 October 2021].
Dailymed.nlm.nih.gov. 2021. Isosorbide Dinitrate Tablets, USP (Oral). [online] Available at: [Accessed 19 October 2021].
Related Questions
Question:
Dear Doctors, my father had a cardiovascular surgery for placing a stent in his heart. He started ha...more
Answer from Dr. Parag Jaipuriya
i think for ur medical kidney disorder u need to consult nephrologist.....he wil...more
Question:
My mother has restrictive cardiomyopathy, tricuspid regurgitation and pulmonary hypertension.
Doc...more
Answer from Dr. K.Naga Murali
Better to avoid that combination
Question:
Dear Doctors, my father is 76 years old now and he was diagnosed with triple vessel coronary artery...more
Answer from Dr. Nikhila Pachani
Tablet Isolazine is a combination of isosorbide dinitrate and hydralazine. This ...more
Question:
Can Tryptomer 10 mg be given to a 67 years CKD patient on dialysis with recent onset of insomnia con...more
Answer from Dr. Anvesh Parmar
Can help you next course of action and treatment plan. Would like to discuss in ...more
Question:
My father was operated CABG last year AND it was reported that he had low LVEF even after grafting.
...more
Answer from Dr. Suresh Bhagia
Newer medicines are available for low EF now.
Information on this page was last updated on 27 Feb 2023
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.