Atherosclerotic heart disease is more common in immunocompromised patients.It is about two to three times higher than non HIV population.Mortality due heart disease specially coronary heart disease is top most in death epidemiology report in 2018.Scientisys including UVA's client L Miller, have 8dentifoed nearly a dozen genes linked to calcium buildup in coronary artery,contributing to ,contributing to life threatening CAD.The findings published in nature genetics,,suggests potential Target tos tfor medications or nutritional supplements to slow or prevent disease progression a critical step in primary prevention.