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HLA B-27 Query
I had HLA B-27 positive in 2007 according to a Lab report from a famous diagnostic center and i was treated for ankylosing spondylitis and it was controlled. later again in year 2016 I started having familiar pain and on visiting a doctor i was asked for the same test again. The test Result came negative this time(from other diag center. Is it possible for the test to be negative? If not then was it a necessary for the doctor to ask me for the test again if he knew i have HLA b-27 positive?
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HLA  B 27 ANTIGEN. Human leukocyte antigen B27 (HLA-B27) is a protein located on the surface of your white blood cells. An HLA-B27 test is a blood test that identifies HLA-B27 proteins. Human leukocyte antigens (HLAs) are proteins commonly found on white blood cells. These antigens help your immune system identify the differences between healthy body tissue and foreign substances that may cause infection. Although most HLAs protect your body from harm, HLA-B27 is a specific type of protein that contributes to immune system dysfunction. The presence of HLA-B27 on your white blood cells can cause your immune system to attack those otherwise healthy cells. When this occurs, it can result in an autoimmune disease or immune-mediated disease, such as juvenile rheumatoid arthritis or ankylosing spondylitis. TEST PURPOSE Monitoring disease progression The presence of HLA-B27 is associated with certain autoimmune and immune-mediated diseases, including: ankylosing spondylitis, which causes inflammation of the bones in your spine reactive arthritis, which causes inflammation of your joints, urethra, and eyes, and sometimes lesions on your skin juvenile rheumatoid arthritis anterior uveitis, which causes swelling and irritation in the middle layer of your eye A doctor may order the HLA-B27 test to monitor the progression of these and other autoimmune diseases. DIAGNOSTIC VALUE. For people with specific symptoms, the HLA-B27 test may be used along with other blood, urine, or imaging tests to confirm the diagnosis of an autoimmune disease. The symptoms that might prompt a doctor to order the test include: joint pain stiffness or swelling of your spine, neck, or chest inflammation of your joints or urethra accompanied by skin lesions recurring inflammation in your eye Your doctor can order HLA antigen tests, including tests for HLA-B27, when you’re undergoing a kidney or bone marrow transplant. These tests can be used to ensure a suitable match between you and a donor. RESULT INTERPRETATION 1.IF NEGATIVE A negative test indicates the absence of HLA-B27 in your blood. However, if the test is negative, it doesn’t mean that you don’t have an autoimmune disorder. When making a final diagnosis, your doctor will consider all test results along with your symptoms. Sometimes people with autoimmune disorders don’t have HLA-B27 on their white blood cells. 2.IF POSITIVE. If the test is positive, this means that HLA-B27 is present in your blood. Although a positive result may be cause for concern, the presence of the antigen doesn’t always mean that an autoimmune disorder will develop. Diagnosis of an autoimmune disorder must be made based on your symptoms and the results of all blood tests and diagnostic exams. Ur Problem POSITIVE  HLA B-27 ANTIGEN TEST CAME NEGATIVE AND VICE VERSA. Technically speaking, this can never happen. HLA-b27 is a genetic marker & just like a blood group it can never change. In that case, what can go wrong? Let us now understand how the HLA-B27 gene is tested. It is processed using three different methods Microlymphocytotoxicity (MLCT) Flowcytometry (FC) DNA based typing using a Polymerase chain reaction based assays (PCR) The methods are arranged in the order of their accuracy with PCR based method being the most accurate. A few patients that test negative with Flowcytometry method do turn out to be positive with the PCR method. Flowcytometry can also give an ‘indeterminate’ (inconclusive) report that needs to be rechecked with a PCR based method. This is how the discrepancy in subsequent tests sets in. So the next time to get your HLAB27 checked; do have a look at the method as well. I NEED UR DETAILED HISTORY INVESTIGATION AND PREVIOUS TREAMENT DETAILS TO EVALUATE UR EXACT DIAGNOSIS AND TREATMENT. I HAVE VERY GOOD AYURVEDIC TREATMENT LIKE BEST IMMUNOMODULATORS WHICH ALLOPATHY( DON'T HAVE AND FULL OF SIDE EFFECTS) FOR ALL AUTOIMMUNE DISEASES . I ASSURE GOOD RESULTS AND BETTER LIFE STLYE COMPAIRED TO ALLOPATHY. AYURVEDIC TREATMENT SAFE.EFFECTIVE. NO SIDE EFFECTS. U CAN CONSULT ME FOR UR PROBLEMS. I WISH HAPPY HEALTHY AND PROSPORIUS LIFE AHEAD. GOD BLESS U.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.