Long-term side effects of PPI are diarrhea, fractures, hypomagnesemia,
vitamin B12 deficiency, chronic
kidney disease, and dementia.
Uses of PPI in GERD and duodena ulcers ranges from 4 weeks upto 8 weeks
Sudden stoppage ofLong-term use of PPI causes rebound acid hypersecetion.Its always better to gradually reduce the ppi dosage and stop