Hello Rounak,
India being an endemic population for Typhoid fever, the general level of antibodies is usually higher and therefore insignificant without clinic correlation.
Moreover, As with all serological tests, the rise in antibody levels needed to perform the diagnosis takes about 7–14 days, which limits its applicability in early diagnosis.
The Widal test is positive if TO antigen titre is more than 1:160 in an active infection, or if TH antigen titer is more than 1:160 in past infection or in immunized persons. A single Widal test is of little clinical relevance due to the high number of cross-reacting infections, including malaria. If no other tests (either bacteriologic culture or more specific serology) are available, a fourfold increase in the titer (e.g., from 1:40 to 1:160) in the course of the infection, or a conversion from an IgM reaction to an IgG reaction of at least the same titer, would be consistent with a typhoid infection.
Get better soon.
Answered2018-05-23 14:39:00
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