An estradiol (E2) of 76 pg/mL is above the normal male range (usually 10-40 pg/mL) and warrants investigation even without steroid use. The most common natural cause is excess conversion of
testosterone to estradiol by the aromatase enzyme, which is more active in adipose (fat) tissue â so body fat percentage is a key factor.
Liver function also affects estrogen clearance. Your testosterone at 618 ng/dL is healthy, so the elevated E2 is likely due to increased aromatization rather than a production problem. Causes like adrenal or testicular tumors are less likely but should be ruled out.
Next Steps
See an endocrinologist for a full hormonal workup â include
LH,
FSH,
prolactin,
liver function tests, and
thyroid. An ultrasound of the testes and adrenals may also be recommended. Lifestyle measures like reducing body fat percentage can naturally lower E2 levels. Please consult me directly on Practo for a detailed evaluation.