Guilt is a powerful negative and yet essential emotion of for us. Dealing with it constantly sometimes can take a toll on physical health as well as emotional health. Instead of avoiding guilt or struggling with it, working on guilt issues is required. Overwhelming guilt, wishing to die are common symptoms of mood disorder - depression. Individual psychotherapy along with medication may help a lot. Best to consult a psychiatrist or a Clinical Psychologist to evaluate your difficulty and figure out further help.